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  1. Thalidomide based regimen is an effective and well tolerated therapy in multiple myeloma (MM) patients, however, there were a small number of studies written about the results of thalidomide therapy in non-tra...

    Authors: Pimjai Niparuck, Ladda Sorakhunpipitkul, Vichai Atichartakarn, Suporn Chuncharunee, Artit Ungkanont, Pantep Aungchaisuksiri, Teeraya Puavilai and Saengsuree Jootar

    Citation: Journal of Hematology & Oncology 2010 3:1

    Content type: Letter to the Editor

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  2. We have described a severe combined immunodeficiency (SCID) mouse model that permits the subcutaneous growth of primary human acute leukemia blast cells into a measurable subcutaneous nodule which may be follo...

    Authors: Ying Yan, Eric A Wieman, Xiuqin Guan, Ann A Jakubowski, Peter G Steinherz and Richard J O'Reilly

    Citation: Journal of Hematology & Oncology 2009 2:51

    Content type: Research

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  3. The last two decades have witnessed striking advances in our understanding of the biological factors underlying the development of Follicular lymphoma (FL). Development of newer treatment approaches have impro...

    Authors: Nishant Tageja, Subhash Padheye, Prasad Dandawate, Ayad Al-Katib and Ramzi M Mohammad

    Citation: Journal of Hematology & Oncology 2009 2:50

    Content type: Review

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  4. The International Prognostic Index (IPI) is used to determine prognosis in diffuse large B-cell lymphoma (DLBCL). One of the determinants of IPI is the stage of disease with bone marrow involvement being class...

    Authors: Dipti Talaulikar, Bruce Shadbolt, Jane E Dahlstrom and Anne McDonald

    Citation: Journal of Hematology & Oncology 2009 2:49

    Content type: Research

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  5. Pulmonary involvement and skin involvement are rare complications of plasma cell neoplasms. Here we describe what may be the first reported case of a patient with relapse in both of these sites following autol...

    Authors: Yuan Yuan, Rosemary Wieczorek, David L Green, Perry Cook, Harold Ballard and David J Araten

    Citation: Journal of Hematology & Oncology 2009 2:48

    Content type: Letter to the Editor

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  6. Plasmablastic lymphoma (PL) is a subtype of diffuse large B-cell lymphoma (DLBCL). Studies have suggested that tumors with PL morphology represent a group of neoplasms with clinopathologic characteristics corr...

    Authors: Chung-Che Chang, Xiaobo Zhou, Jesalyn J Taylor, Wan-Ting Huang, Xianwen Ren, Federico Monzon, Yongdong Feng, Pulivarthi H Rao, Xin-Yan Lu, Facchetti Fabio, Susan Hilsenbeck, Chad J Creighton, Elaine S Jaffe and Ching-Ching Lau

    Citation: Journal of Hematology & Oncology 2009 2:47

    Content type: Short report

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  7. Tyrosine kinase inhibitors (TKIs) like dasatinib and nilotinib are indicated as second-line treatment for chronic myeloid leukemia resistant or intolerant to the current first-line TKI imatinib. These are agen...

    Authors: David Masiello, Gerry Gorospe III and Allen S Yang

    Citation: Journal of Hematology & Oncology 2009 2:46

    Content type: Review

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  8. Recent studies have suggested that the presence of iron overload prior to stem cell transplantation is associated with decreased survival. Within these studies, the criteria used to define iron overload have v...

    Authors: Jonathan A Storey, Rebecca F Connor, Zachary T Lewis, David Hurd, Gregory Pomper, Yi K Keung, Manisha Grover, James Lovato, Suzy V Torti, Frank M Torti and István Molnár

    Citation: Journal of Hematology & Oncology 2009 2:44

    Content type: Research

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  9. Activated Protein C [APC] improves outcome in immunocompetent patients with severe sepsis particularly in those who are perceived to have high mortality risk. Before embarking on a trial of APC administration ...

    Authors: Rakshit Panwar, Bala Venkatesh, Peter Kruger, Robert Bird, Devinder Gill, Leo Nunnink and Goce Dimeski

    Citation: Journal of Hematology & Oncology 2009 2:43

    Content type: Research

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  10. The occurrence of chronic myeloid leukemia in pregnancy is rare and its management poses a clinical challenge for physicians treating these patients. We report a 30-year-old woman with chronic myeloid leukemia...

    Authors: Monika Conchon, Sabri S Sanabani, Israel Bendit, Fernanda Maria Santos, Mariana Serpa and Pedro Enrique Dorliac-Llacer

    Citation: Journal of Hematology & Oncology 2009 2:42

    Content type: Case report

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  11. Hereditary spherocytosis (HS) is a genetic disorder of the red blood cell membrane clinically characterized by anemia, jaundice and splenomegaly. Evans' syndrome is a clinical syndrome characterized by autoimm...

    Authors: Hideki Yoshida, Hiroyuki Ishida, Takao Yoshihara, Takashi Oyamada, Masataka Kuwana, Toshihiko Imamura and Akira Morimoto

    Citation: Journal of Hematology & Oncology 2009 2:40

    Content type: Case report

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  12. Lymphomatoid granulomatosis (LG) is a rare, Epstein-Barr virus (EBV)-associated systemic angiodestructive lymphoproliferative disorder that may progress to a diffuse large B cell lymphoma. Pulmonary involvemen...

    Authors: Ashima Makol, Kalyan Kosuri, Deimante Tamkus, Wanderley de M Calaca and Howard T Chang

    Citation: Journal of Hematology & Oncology 2009 2:39

    Content type: Case report

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  13. Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated. There is ample data ...

    Authors: Subhash Padhye, Aamir Ahmad, Nikhil Oswal and Fazlul H Sarkar

    Citation: Journal of Hematology & Oncology 2009 2:38

    Content type: Review

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  14. The general enhanced expression of α1-antichymotrypsin (ACT), clusterin (CLU), α1-antitrypsin (AAT), haptoglobin β-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian ...

    Authors: Yeng Chen, Boon-Kiong Lim and Onn H Hashim

    Citation: Journal of Hematology & Oncology 2009 2:37

    Content type: Research

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  15. Immunomodulatory drugs lenalidomide and pomalidomide are synthetic compounds derived by modifying the chemical structure of thalidomide to improve its potency and reduce its side effects. Lenalidomide is a 4-a...

    Authors: Venumadhav Kotla, Swati Goel, Sangeeta Nischal, Christoph Heuck, Kumar Vivek, Bhaskar Das and Amit Verma

    Citation: Journal of Hematology & Oncology 2009 2:36

    Content type: Review

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  16. The complete pathological response after primary chemotherapy could represent an important prognostic factor in patients affected by colorectal liver metastases.

    Authors: Norma Malavasi, Giovanni Ponti, Roberta Depenni, Federica Bertolini, Sandra Zironi, Gabriele Luppi and Pier Franco Conte

    Citation: Journal of Hematology & Oncology 2009 2:35

    Content type: Case report

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  17. Ex vivo activation and expansion of lymphocytes for adoptive cell therapy has demonstrated great success. To improve safety and therapeutic efficacy, increased antigen specificity and reduced non-specific respons...

    Authors: Shuhong Han, Yuju Huang, Yin Liang, Yuchin Ho, Yichen Wang and Lung-Ji Chang

    Citation: Journal of Hematology & Oncology 2009 2:34

    Content type: Research

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  18. The response to remission induction in elderly patients with acute myeloid leukemia (AML) remains poor. The purpose of this paper is to evaluate the efficacy and toxicity of a plant alkaloid, homoharringtonine...

    Authors: Jianmin Wang, Shuqing Lü, Jianmin Yang, Xianmin Song, Li Chen, Chongmei Huang, Jun Hou and Weiping Zhang

    Citation: Journal of Hematology & Oncology 2009 2:32

    Content type: Short report

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  19. Vorinostat (Zolinza®), a histone deacetylase inhibitor, was approved by the US Food and Drug Administration in October 2006 for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma...

    Authors: David Siegel, Mohamad Hussein, Chandra Belani, Francisco Robert, Evanthia Galanis, Victoria M Richon, José Garcia-Vargas, Cesar Sanz-Rodriguez and Syed Rizvi

    Citation: Journal of Hematology & Oncology 2009 2:31

    Content type: Review

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  20. In the last decade the importance of ethnicity, socio-economic and gender differences in relation to disease incidence, diagnosis, and prognosis has been realized. Differences in these areas have become a majo...

    Authors: Justin P Lee, Elliott Birnstein, David Masiello, Dongyun Yang and Allen S Yang

    Citation: Journal of Hematology & Oncology 2009 2:30

    Content type: Research

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  21. Advances in the treatment of chronic lymphocytic leukemia (CLL) have improved initial overall response (OR) rates, complete response (CR) rates and progression free survival (PFS). Despite these advances, CLL ...

    Authors: Kami J Maddocks and Thomas S Lin

    Citation: Journal of Hematology & Oncology 2009 2:29

    Content type: Review

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  22. RIZ1 expression and activity are reduced in many cancers. In AML cell lines and patient material, RIZ1 expression is reduced relative to normal bone marrow. In chronic myelogenous leukemia (CML), blastic trans...

    Authors: Ashakumary Lakshmikuttyamma, Naoto Takahashi, Elodie Pastural, Emina Torlakovic, Hesham M Amin, Guillermo Garcia-Manero, Michael Voralia, Magdalena Czader, John F DeCoteau and C Ronald Geyer

    Citation: Journal of Hematology & Oncology 2009 2:28

    Content type: Short report

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  23. Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD...

    Authors: Michihide Tokuhira, Kyoko Hanzawa, Reiko Watanabe, Yasunobu Sekiguchi, Tomoe Nemoto, Yasuo Toyozumi, Jun-ichi Tamaru, Shinji Itoyama, Katsuya Suzuki, Hideto Kameda, Shigehisa Mori and Masahiro Kizaki

    Citation: Journal of Hematology & Oncology 2009 2:27

    Content type: Case report

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  24. Patients suffering from adult acute lymphoblastic leukemia are acutely ill and present most commonly with fever, pallor, bleeding, lymphadenopathy, hepatosplenomegaly and presence of lymphoblasts in the periph...

    Authors: Farhat Abbas Bhatti, Iftikhar Hussain and Muhammad Zafar Ali

    Citation: Journal of Hematology & Oncology 2009 2:26

    Content type: Case report

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  25. Non-prescriptional use of medicinal herbs among cancer patients is common around the world. The alleged anti-cancer effects of most herbal extracts are mainly based on studies derived from in vitro or in vivo ani...

    Authors: Godfrey Chi-Fung Chan, Wing Keung Chan and Daniel Man-Yuen Sze

    Citation: Journal of Hematology & Oncology 2009 2:25

    Content type: Review

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  26. The ability to screen blood of early stage operable breast cancer patients for circulating tumour cells is of potential importance for identifying patients at risk of developing distant relapse. We present the...

    Authors: Michael P Raynor, Sally-Anne Stephenson, Kenneth B Pittman, David CA Walsh, Michael A Henderson and Alexander Dobrovic

    Citation: Journal of Hematology & Oncology 2009 2:24

    Content type: Research

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  27. Acute myeloid leukemia (AML) is a heterogenous disorder that results from a block in the differentiation of hematopoietic progenitor cells along with uncontrolled proliferation. In approximately 60% of cases, ...

    Authors: Tara K Gregory, David Wald, Yichu Chen, Johanna M Vermaat, Yin Xiong and William Tse

    Citation: Journal of Hematology & Oncology 2009 2:23

    Content type: Review

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  28. Cisplatin depletes MGMT and increases the sensitivity of leukemia cells to temozolomide. We performed a phase I study of cisplatin and temozolomide in patients with relapsed and refractory acute leukemia. Fift...

    Authors: Karen Seiter, Sreedhar Katragadda, Doris Ponce, Muhammad Rasul and Nasir Ahmed

    Citation: Journal of Hematology & Oncology 2009 2:21

    Content type: Short report

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  29. Ezatiostat hydrochloride liposomes for injection, a glutathione S-transferase P1-1 inhibitor, was evaluated in myelodysplastic syndrome (MDS). The objectives were to determine the safety, pharmacokinetics, and...

    Authors: Azra Raza, Naomi Galili, Natalie Callander, Leonel Ochoa, Lawrence Piro, Peter Emanuel, Stephanie Williams, Howard Burris III, Stefan Faderl, Zeev Estrov, Peter Curtin, Richard A Larson, James G Keck, Marsha Jones, Lisa Meng and Gail L Brown

    Citation: Journal of Hematology & Oncology 2009 2:20

    Content type: Research

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  30. Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder of unknown etiology and characterized by various clinical manifestations and multiple organ involvement. It has been reported in as...

    Authors: Zhen-gang Yuan, Xiao-yi Dun, Yong-hua Li and Jian Hou

    Citation: Journal of Hematology & Oncology 2009 2:19

    Content type: Case report

    Published on:

  31. Individualized therapies that are tailored to a patient's genetic composition will be of tremendous value for treatment of cancer. Recently, Kirsten ras (KRAS) status has emerged as a predictor of response to epi...

    Authors: David Z Chang, Vikas Kumar, Ying Ma, Kuiyuan Li and Scott Kopetz

    Citation: Journal of Hematology & Oncology 2009 2:18

    Content type: Review

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  32. We studied serum proteomic profiling in patients with graft versus host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) by two-dimensional gel electrophoresis (2-DE) and mass spec...

    Authors: Joseph McGuirk, Gang Hao, Weijian Hou, Sunil Abhyankar, Casey Williams, Weisi Yan, Jianda Yuan, Xiuqin Guan, Robert Belt, Shaun Dejarnette, Jeffery Wieman and Ying Yan

    Citation: Journal of Hematology & Oncology 2009 2:17

    Content type: Research

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  33. Malignant tumors that involve the skull base pose significant challenges to the clinician because of the proximity of critical neurovascular structures and limited effectiveness of surgical resection without m...

    Authors: Nicholas D Coppa, Daniel MS Raper, Ying Zhang, Brian T Collins, K William Harter, Gregory J Gagnon, Sean P Collins and Walter C Jean

    Citation: Journal of Hematology & Oncology 2009 2:16

    Content type: Research

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  34. Human β-globin disorders are relatively common genetic diseases cause by mutations in the β-globin gene. Increasing the expression of the γ-globin gene has great benefits in reducing complications associated with...

    Authors: Xiaoxin S Xu, Xin Hong and Gan Wang

    Citation: Journal of Hematology & Oncology 2009 2:15

    Content type: Research

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  35. R-CHOP (rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) and R-CVP (rituximab with cyclophosphamide, vincristine and prednisone) have both been used successfully in the treatment of pa...

    Authors: Ganguly Siddhartha and Patel Vijay

    Citation: Journal of Hematology & Oncology 2009 2:14

    Content type: Research

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  36. Metastatic pancreatic adenocarcinoma has a short median overall survival (OS) of 5–6 months. However, a subgroup of patients survives more than 1 year. We analyzed the survival outcomes of this subgroup and ev...

    Authors: Bernardo HL Goulart, Jeffrey W Clark, Gregory Y Lauwers, David P Ryan, Nina Grenon, Alona Muzikansky and Andrew X Zhu

    Citation: Journal of Hematology & Oncology 2009 2:13

    Content type: Research

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  37. Cholestatic jaundice as a presenting symptom of Precursor T-lymphoblastic leukemia (T-ALL)/lymphoma (T-LBL) has never been reported in literature. Similarly, precursor T-ALL/T-LBL is characteristically negativ...

    Authors: Kevin J Patel, Sahibzada U Latif and Wanderley M de Calaca

    Citation: Journal of Hematology & Oncology 2009 2:12

    Content type: Case report

    Published on:

  38. Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma (ALK-DLBCL) is a rare lymphoma with several clinicopathological differences from ALK-positive anaplastic large cell lymphoma (ALCL). The latest...

    Authors: Brady Beltran, Jorge Castillo, Renzo Salas, Pilar Quiñones, Domingo Morales, Fernando Hurtado, Luis Riva and Eric Winer

    Citation: Journal of Hematology & Oncology 2009 2:11

    Content type: Case report

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  39. We have reviewed the pivotal presentations rcelated to colorectal cancer (CRC) and other gastrointestinal malignancies from 2008 annual meeting of the American Society of Clinical Oncology (ASCO). We have disc...

    Authors: Milind Javle and Chung-Tsen Hsueh

    Citation: Journal of Hematology & Oncology 2009 2:9

    Content type: Review

    Published on:

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