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  2. Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.

    Authors: Santiago Schiaffino-Ortega, Carlos Balinas, Marta Cuadros and Pedro P Medina
    Citation: Journal of Hematology & Oncology 2014 7:81
    Content type: Research highlight Published on:

  3. Here, we report and investigate the genomic alterations of two novel cases of Non-Hodgkin Lymphoma (NHL) in children with Williams-Beuren syndrome (WBS), a multisystem disorder caused by 7q11.23 hemizygous del...

    Authors: David Guenat, Samuel Quentin, Carmelo Rizzari, Catarina Lundin, Tiziana Coliva, Patrick Edery, Helen Fryssira, Laurent Bermont, Christophe Ferrand, Jean Soulier, Christophe Borg and Pierre-Simon Rohrlich
    Citation: Journal of Hematology & Oncology 2014 7:82
    Content type: Letter to the Editor Published on:

  4. Leukemia is a systemic malignancy originated from hematopoietic cells. The extracellular environment has great impacts on the survival, proliferation and dissemination of leukemia cells. The spleen is an impor...

    Authors: Shihui Ma, Yingxu Shi, Yakun Pang, Fang Dong, Hui Cheng, Sha Hao, Jing Xu, Xiaofan Zhu, Weiping Yuan, Tao Cheng and Guoguang Zheng
    Citation: Journal of Hematology & Oncology 2014 7:71
    Content type: Research Published on:

  5. Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is...

    Authors: Ying Shao, Zhongjian Cheng, Xinyuan Li, Valeria Chernaya, Hong Wang and Xiao-feng Yang
    Citation: Journal of Hematology & Oncology 2014 7:80
    Content type: Review Published on:

  6. Recently it was reported that microRNA from the miR-17 ~ 92 family may have a key role in chronic lymphocytic leukemia (CLL). Here, we designed specific oligonucleotides to target endogenous miR-17 (antagomiR17)....

    Authors: Sara Dereani, Paolo Macor, Tiziana D’Agaro, Nelly Mezzaroba, Michele Dal-Bo, Sara Capolla, Antonella Zucchetto, Erika Tissino, Giovanni Del Poeta, Sonia Zorzet, Valter Gattei and Riccardo Bomben
    Citation: Journal of Hematology & Oncology 2014 7:79
    Content type: Letter to the Editor Published on:

  7. Renal cell carcinoma (RCC) is a complex with diverse biological characteristics and distinct molecular signature. New target therapies to molecules that drive RCC initiation and progression have achieved promi...

    Authors: Qian Chu, Na Han, Xun Yuan, Xin Nie, Hua Wu, Yu Chen, Mingzhou Guo, Shiying Yu and Kongming Wu
    Citation: Journal of Hematology & Oncology 2014 7:73
    Content type: Research Published on:

  9. The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with ...

    Authors: Yajuan Cui, Bing Li, Robert Peter Gale, Qian Jiang, Zefeng Xu, Tiejun Qin, Peihong Zhang, Yue Zhang and Zhijian Xiao
    Citation: Journal of Hematology & Oncology 2014 7:77
    Content type: Letter to the Editor Published on:

  10. The identification of fusion genes such as SYT-SSX1/SSX2, PAX3-FOXO1, TPM3/TPM4-ALK and EWS-FLI1 in human sarcomas has provided important insight into the diagnosis and targeted therapy of sarcomas. No recurrent ...

    Authors: Jilong Yang, Matti Annala, Ping Ji, Guowen Wang, Hong Zheng, David Codgell, Xiaoling Du, Zhiwei Fang, Baocun Sun, Matti Nykter, Kexin Chen and Wei Zhang
    Citation: Journal of Hematology & Oncology 2014 7:76
    Content type: Research Published on:

  11. Exportin 1 (XPO1), also called chromosome region maintenance 1 (CRM1), is the sole exportin mediating transport of many multiple tumor suppressor proteins out of the nucleus.

    Authors: Giovanni Luca Gravina, Monica Tortoreto, Andrea Mancini, Alessandro Addis, Ernesto Di Cesare, Andrea Lenzi, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham, Nadia Zaffaroni and Claudio Festuccia
    Citation: Journal of Hematology & Oncology 2014 7:46
    Content type: Research Published on:

  12. De novo acute myeloid leukemia (AML) with concurrent DNMT3A, FLT3 and NPM1 mutations (AML DNMT3A/FLT3/NPM1 ) has been suggested to represent a unique AML subset on the basis ...

    Authors: Sanam Loghavi, Zhuang Zuo, Farhad Ravandi, Hagop M Kantarjian, Carlos Bueso-Ramos, Liping Zhang, Rajesh R Singh, Keyur P Patel, L Jeffrey Medeiros, Francesco Stingo, Mark Routbort, Jorge Cortes, Rajyalakshmi Luthra and Joseph D Khoury
    Citation: Journal of Hematology & Oncology 2014 7:74
    Content type: Research Published on:

  14. Technological advancements in the molecular characterization of cancers have enabled researchers to identify an increasing number of key molecular drivers of cancer progression. These discoveries have led to m...

    Authors: Alan D Smith, Desam Roda and Timothy A Yap
    Citation: Journal of Hematology & Oncology 2014 7:70
    Content type: Review Published on:

  15. Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T ce...

    Authors: Xuebin Ji, Liping Zhang, Jun Peng and Ming Hou
    Citation: Journal of Hematology & Oncology 2014 7:72
    Content type: Review Published on:

  16. It has recently been reported that the extracts of green tea polyphenol have cancer preventive effects. In this study, we investigated the effect of the natural composition from green tea leaves Catechins on a...

    Authors: Li Zhang, Qiu-Sheng Chen, Peng-Peng Xu, Ying Qian, Ai-Hua Wang, Dan Xiao, Yan Zhao, Yan Sheng, Xiang-Qin Wen and Wei-Li Zhao
    Citation: Journal of Hematology & Oncology 2014 7:75
    Content type: Research Published on:

  17. Studying DNA methylation changes in the context of structural rearrangements and point mutations as well as gene expression changes enables the identification of genes that are important for disease onset and ...

    Authors: Hana Hájková, Markus Hsi-Yang Fritz, Cedrik Haškovec, Jiří Schwarz, Cyril Šálek, Jana Marková, Zdeněk Krejčík, Michaela Dostálová Merkerová, Arnošt Kostečka, Martin Vostrý, Ota Fuchs, Kyra Michalová, Petr Cetkovský and Vladimír Beneš
    Citation: Journal of Hematology & Oncology 2014 7:66
    Content type: Short report Published on:

  18. Head and neck squamous cell carcinoma (HNSCC) mortality rates have not shown significant reduction in decades. Platelets are being implicated in having cancer-promoting roles, an observation supported by the a...

    Authors: Saleh Rachidi, Kristin Wallace, Terry A Day, Anthony J Alberg and Zihai Li
    Citation: Journal of Hematology & Oncology 2014 7:65
    Content type: Research Published on:

  19. CCAAT/enhancer-binding protein-α (CEBPA) is a critical regulator of myeloid differentiation. Disruption of CEBPA function contributes to the development of acute myeloid leukemia (AML). CEBPA regulates a large nu...

    Authors: James M Hughes, Beatrice Salvatori, Federico M Giorgi, Irene Bozzoni and Alessandro Fatica
    Citation: Journal of Hematology & Oncology 2014 7:69
    Content type: Letter to the Editor Published on:

  20. The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an ac...

    Authors: Yoshiaki Chinen, Natsumi Sakamoto, Hisao Nagoshi, Tomohiko Taki, Saori Maegawa, Shotaro Tatekawa, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Mio Yamamoto-Sugitani, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Junya Kuroda and Masafumi Taniwaki
    Citation: Journal of Hematology & Oncology 2014 7:68
    Content type: Letter to the Editor Published on:

  21. Non-Hodgkin lymphomas (NHLs) account for 4% of all malignancies. 5-year survival rate increased to 50% with new treatment modalities, however there is need for new effective treatment for the more aggressive, ...

    Authors: Alexandra Aronin, Shira Amsili, Tatyana B Prigozhina, Kobi Tzdaka, Roy Shen, Leonid Grinmann, Fanny Szafer, Per Edebrink, Mari-Anne Rauvola, Noam Shani and Michal Dranitzki Elhalel
    Citation: Journal of Hematology & Oncology 2014 7:64
    Content type: Research Published on:

  22. The aim of this study was to analyze the long-term survival of AML patients with CEBPA mutations.

    Authors: Friederike Pastore, Daniela Kling, Eva Hoster, Annika Dufour, Nikola P Konstandin, Stephanie Schneider, Maria C Sauerland, Wolfgang E Berdel, Thomas Buechner, Bernhard Woermann, Jan Braess, Wolfgang Hiddemann and Karsten Spiekermann
    Citation: Journal of Hematology & Oncology 2014 7:55
    Content type: Research Published on:

  23. The CD20-directed monoclonal antibody rituximab established a new era in lymphoma therapy. Since then other epitopes on the lymphoma surface have been identified as potential targets for monoclonal antibodies ...

    Authors: Tejas Suresh, Lisa X Lee, Jitesh Joshi and Stefan K Barta
    Citation: Journal of Hematology & Oncology 2014 7:58
    Content type: Review Published on:

  24. Identification of novel genetic risk factors is imperative for a better understanding of B lymphomagenesis and for the development of novel therapeutic strategies. TRAF3, a critical regulator of B cell surviva...

    Authors: Shanique KE Edwards, Jacqueline Baron, Carissa R Moore, Yan Liu, David H Perlman, Ronald P Hart and Ping Xie
    Citation: Journal of Hematology & Oncology 2014 7:56
    Content type: Research Published on:

  25. FENDRR is a long non-coding RNAs (lncRNA) that binds to polycomb repressive complexe 2 (PRC2) to epigenetically regulate the expression of its target gene. The clinical role of FENDRR in carcinomas remains yet to...

    Authors: Tong-peng Xu, Ming-de Huang, Rui Xia, Xin-xin Liu, Ming Sun, Li Yin, Wen-ming Chen, Liang Han, Er-bao Zhang, Rong Kong, Wei De and Yong-qian Shu
    Citation: Journal of Hematology & Oncology 2014 7:63
    Content type: Research Published on:

  26. Improvement of current GVHD prophylactic therapies remains an important goal in the allo-HSCT. We have described a novel prophylaxis regimen in a single institution trial. The Chinese Bone Marrow Transplant Co...

    Authors: Yong-rong Lai, Yu-hong Chen, Deng-ming Hu, Ming Jiang, Qi-fa Liu, Lin Liu, Jian Hou, Paul Schwarzenberger, Qiao-chuan Li, Zhong-ming Zhang, Kai-yan Liu and Xiao-jun Huang
    Citation: Journal of Hematology & Oncology 2014 7:59
    Content type: Research Published on:

  27. Survivin is overexpressed in cancer cells and plays a crucial role in apoptosis evasion. YM155, a small-molecule inhibitor of survivin, could enhance the cytotoxicity of various DNA-damaging agents. Here, we e...

    Authors: Qin Qin, Hongyan Cheng, Jing Lu, Liangliang Zhan, Jianchao Zheng, Jing Cai, Xi Yang, Liping Xu, Hongcheng Zhu, Chi Zhang, Jia Liu, Jianxin Ma, Xizhi Zhang, Shengbin Dai and Xinchen Sun
    Citation: Journal of Hematology & Oncology 2014 7:62
    Content type: Research Published on:

  28. Telomeres are specific nucleoprotein structures at the ends of eukaryotic chromosomes. Telomeres and telomere-associated proteins maintain genome stability by protecting the ends of chromosomes from fusion and...

    Authors: Limengmeng Wang, Haowen Xiao, Xing Zhang, Chong Wang and He Huang
    Citation: Journal of Hematology & Oncology 2014 7:61
    Content type: Review Published on:

  29. Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in th...

    Authors: Johana M Isaza-Correa, Zheng Liang, Anke van den Berg, Arjan Diepstra and Lydia Visser
    Citation: Journal of Hematology & Oncology 2014 7:57
    Content type: Review Published on:

  30. The aberrant hemostasis is a common manifestation of cancer, and venous thromboembolism (VTE) is the second leading cause of cancer patients’ mortality. Tissue factor (TF), comprising of a 47-kDa transmembrane...

    Authors: Xiao Han, Bo Guo, Yongsheng Li and Bo Zhu
    Citation: Journal of Hematology & Oncology 2014 7:54
    Content type: Review Published on:

  31. Acute myeloid leukemia (AML) remains a difficult disease to treat and requires new therapies to improve treatment outcome. Wee1 inhibitors have been used to prevent activation of the G2 cell cycle checkpoint, ...

    Authors: Wenxiu Qi, Chengzhi Xie, Chunhuai Li, J Timothy Caldwell, Holly Edwards, Jeffrey W Taub, Yue Wang, Hai Lin and Yubin Ge
    Citation: Journal of Hematology & Oncology 2014 7:53
    Content type: Research Published on:

  32. Germ cell tumors (GCT) are the most common solid tumors in adolescent and young adult males (age 15 and 35 years) and remain one of the most curable of all solid malignancies. However a subset of patients will...

    Authors: Vivek Subbiah, Funda Meric-Bernstam, Gordon B Mills, Kenna R Mills Shaw, Ann Marie Bailey, Priya Rao, John F Ward and Lance C Pagliaro
    Citation: Journal of Hematology & Oncology 2014 7:52
    Content type: Research Published on:

  33. TERT promoter mutations were recently discovered in melanoma by next generation sequencing. Subsequently, several malignancies including urothelial carcinoma were also found to be associated with the same TERT pr...

    Authors: Xiaoyong Zheng, Jian Zhuge, Stephania M Bezerra, Sheila F Faraj, Enrico Munari, John T Fallon, Ximing J Yang, Pedram Argani, George J Netto and Minghao Zhong
    Citation: Journal of Hematology & Oncology 2014 7:47
    Content type: Research Published on:

  35. Risk stratification, detection of minimal residual disease (MRD), and implementation of novel therapeutic agents have improved outcome in acute lymphoblastic leukemia (ALL), but survival of adult patients with...

    Authors: Isabelle Bartram, Nicola Gökbuget, Cornelia Schlee, Sandra Heesch, Lars Fransecky, Stefan Schwartz, Reingard Stuhlmann, Kerstin Schäfer-Eckhart, Michael Starck, Albrecht Reichle, Dieter Hoelzer, Claudia D Baldus and Martin Neumann
    Citation: Journal of Hematology & Oncology 2014 7:51
    Content type: Research Published on:

  36. Mutations in JAK2, MPL and CALR are highly relevant to the Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs). We performed high resolution melting analysis and Sanger sequencing togethe...

    Authors: Zhiyuan Wu, Xinju Zhang, Xiao Xu, Yuming Chen, Tingting Hu, Zhihua Kang, Shibao Li, Hua Wang, Weiwei Liu, Xiaochao Ma and Ming Guan
    Citation: Journal of Hematology & Oncology 2014 7:48
    Content type: Research Published on:

  37. Recent advances suggest fallopian tube as the main cellular source for women’s pelvic serous carcinoma (PSC). In addition to TP53 mutations, many other genetic changes are involved in pelvic serous carcinogenesis...

    Authors: Yiying Wang, Yue Wang, Dake Li, Lingmin Li, Wenjing Zhang, Guang Yao, Zhong Jiang and Wenxin Zheng
    Citation: Journal of Hematology & Oncology 2014 7:49
    Content type: Short report Published on:

  38. The Src homology-2 domain protein B (Shb) is an adapter protein operating downstream of several tyrosine kinase receptors and consequently Shb regulates various cellular responses. Absence of Shb was recently ...

    Authors: Karin Gustafsson, Maria Jamalpour, Camilla Trinh, Michael G Kharas and Michael Welsh
    Citation: Journal of Hematology & Oncology 2014 7:45
    Content type: Research Published on:

  39. Patients with DLBCL who are ineligible for or have relapsed after aggressive salvage chemotherapy have a poor prognosis. CD40 is expressed on multiple B-cell neoplasms including DLBCL and is a potential target...

    Authors: Sven de Vos, Andres Forero-Torres, Stephen M Ansell, Brad Kahl, Bruce D Cheson, Nancy L Bartlett, Richard R Furman, Jane N Winter, Henry Kaplan, John Timmerman, Nancy C Whiting, Jonathan G Drachman and Ranjana Advani
    Citation: Journal of Hematology & Oncology 2014 7:44
    Content type: Research Published on:

  40. MicroRNA dysregulation is a common event in leukemia. Polymorphisms in microRNA-binding sites (miRSNPs) in target genes may alter the strength of microRNA interaction with target transcripts thereby affecting ...

    Authors: Agnieszka Dzikiewicz-Krawczyk, Anna Macieja, Ewa Mały, Danuta Januszkiewicz-Lewandowska, Maria Mosor, Marta Fichna, Ewa Strauss and Jerzy Nowak
    Citation: Journal of Hematology & Oncology 2014 7:43
    Content type: Research Published on:

  41. MicroRNAs (miRNAs) are coordinators of cellular differentiation, including granulopoiesis. Although differential expression of many miRNAs is associated with the maturation of granulocytes, analysis of differe...

    Authors: Justin JL Wong, William Ritchie, Dadi Gao, Katherine A Lau, Maria Gonzalez, Anupma Choudhary, Ryan J Taft, John EJ Rasko and Jeff Holst
    Citation: Journal of Hematology & Oncology 2014 7:42
    Content type: Research Published on:

  42. This single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma.

    Authors: M Kay Garcia, Lorenzo Cohen, Ying Guo, Yuhong Zhou, Bing You, Joseph Chiang, Robert Z Orlowski, Donna Weber, Jatin Shah, Raymond Alexanian, Sheeba Thomas, Jorge Romaguera, Liang Zhang, Maria Badillo, Yiming Chen, Qi Wei…
    Citation: Journal of Hematology & Oncology 2014 7:41
    Content type: Research Published on:

  43. Dysregulated microRNA (miRNA) expression contributes to cancer cell proliferation, apoptosis and angiogenesis. Angiogenesis is a hallmark of multiple myeloma (MM) development and progression. Argonaute 2 (AGO2...

    Authors: Shuang Wu, Wenjun Yu, Xiaoyan Qu, Rong Wang, Ji Xu, Qiguo Zhang, Jiaren Xu, Jianyong Li and Lijuan Chen
    Citation: Journal of Hematology & Oncology 2014 7:40
    Content type: Research Published on:

  44. Genetic alterations, including the overexpression of epidermal growth factor receptor (EGFR), play a crucial role in ovarian carcinogenesis. To date, EGFR targeting has shown limited antitumor effects in ovari...

    Authors: Yi Yu, Mingxing Zhang, Xiaoyan Zhang, Qingqing Cai, Shanshan Hong, Wei Jiang and Congjian Xu
    Citation: Journal of Hematology & Oncology 2014 7:39
    Content type: Research Published on:

  45. The uveal melanoma (UM) is the most common human intraocular tumour. Simian Virus 40 (SV-40) is a small DNA tumor virus detected in some malignancies, including the cutaneous melanoma. In this study an indirec...

    Authors: Ilaria Bononi, Paolo Perri, Alice Begnardi, Alessandra Martini, Elisa Mazzoni, Silvia Bosi, Silvia Pietrobon, Adolfo Sebastiani, Mauro Tognon and Fernanda Martini
    Citation: Journal of Hematology & Oncology 2014 7:38
    Content type: Letter to the Editor Published on:

  46. The ABL kinase inhibitor imatinib is highly effective in treating most, but not all, patients with chronic myeloid leukemia (CML). This is because residual CML cells are generally present in the bone marrow mi...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Seiichiro Katagiri, Yuko Tanaka and Kazuma Ohyashiki
    Citation: Journal of Hematology & Oncology 2014 7:37
    Content type: Research Published on:

  47. A 50-year-old woman was diagnosed with acute myeloid leukemia (AML). She has history of thrombocytopenia for 25 years and a significant family history of thrombocytopenia, affecting her mother, siblings and th...

    Authors: Juehua Gao, Ryan D Gentzler, Andrew E Timms, Marshall S Horwitz, Olga Frankfurt, Jessica K Altman and LoAnn C Peterson
    Citation: Journal of Hematology & Oncology 2014 7:36
    Content type: Case report Published on:

    The Erratum to this article has been published in Journal of Hematology & Oncology 2015 8:131

  48. The normal accumulation of adult α and β globins in definitive erythrocytes is critically dependent upon processes that ensure that the cognate mRNAs are maintained at high levels in transcriptionally silent, ...

    Authors: Zhenning He, Decheng Song, Sebastiaan van Zalen and J Eric Russell
    Citation: Journal of Hematology & Oncology 2014 7:35
    Content type: Research Published on:

  49. Expression of CD44 splice isoforms has been previously reported to correlate with inferior outcomes in DLBCL patients treated with CHOP therapy. However, it is unclear whether this observation remains valid in...

    Authors: Xiaolei Wei, Meng Xu, Yongqiang Wei, Fen Huang, Tong Zhao, Xiangzhao Li, Ru Feng and B Hilda Ye
    Citation: Journal of Hematology & Oncology 2014 7:34
    Content type: Letter to the Editor Published on:

  50. CD19 is a B cell lineage specific surface receptor whose broad expression, from pro-B cells to early plasma cells, makes it an attractive target for the immunotherapy of B cell malignancies. In this study we p...

    Authors: Caroline S Breton, Aimable Nahimana, Dominique Aubry, Julie Macoin, Pierre Moretti, Martin Bertschinger, Samuel Hou, Michel A Duchosal and Jonathan Back
    Citation: Journal of Hematology & Oncology 2014 7:33
    Content type: Research Published on:
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Journal of Hematology & Oncology

ISSN: 1756-8722

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