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  1. MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show ...

    Authors: Thilini R Fernando, Norma I Rodriguez-Malave and Dinesh S Rao
    Citation: Journal of Hematology & Oncology 2012 5:7
  2. Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α-ketoglutarate. Acquired somatic mutations of IDH1 and ID...

    Authors: Sadudee Chotirat, Wanna Thongnoppakhun, Orathai Promsuwicha, Chetsada Boonthimat and Chirayu U Auewarakul
    Citation: Journal of Hematology & Oncology 2012 5:5
  3. While lenalidomide (LEN) shows high efficacy in myelodysplastic syndromes (MDS) with del[5q], responses can be also seen in patients presenting without del[5q]. We hypothesized that improved detection of chrom...

    Authors: Yuka Sugimoto, Mikkael A Sekeres, Hideki Makishima, Fabiola Traina, Valeria Visconte, Anna Jankowska, Andres Jerez, Hadrian Szpurka, Christine L O'Keefe, Kathryn Guinta, Manuel Afable, Ramon Tiu, Kathy L McGraw, Alan F List and Jaroslaw Maciejewski
    Citation: Journal of Hematology & Oncology 2012 5:4
  4. Advanced malignant melanoma remains a challenging cancer. Over the past year, there have been 3 agents approved for treatment of melanoma by Food and Drug Administration. These include pegylated interferon alp...

    Authors: Byung Lee, Nikhil Mukhi and Delong Liu
    Citation: Journal of Hematology & Oncology 2012 5:3
  5. Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Chronic Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation/myeloaccumulation without cell maturation impairment. Th...

    Authors: Raquel Tognon, Elainy PL Gasparotto, Renata P Neves, Natália S Nunes, Aline F Ferreira, Patrícia VB Palma, Simone Kashima, Dimas T Covas, Mary Santana, Elizabeth X Souto, Maria Aparecida Zanichelli, Belinda P Simões, Ana Maria de Souza and Fabíola A Castro
    Citation: Journal of Hematology & Oncology 2012 5:2
  6. Speciation of arsenic trioxide (ATO) metabolites in clinical samples such as peripheral blood (PB) from acute promyelocytic leukemia (APL) patients has been conducted. However, speciation of arsenicals in bone...

    Authors: Noriyoshi Iriyama, Yuta Yoshino, Bo Yuan, Akira Horikoshi, Yukio Hirabayashi, Yoshihiro Hatta, Hiroo Toyoda and Jin Takeuchi
    Citation: Journal of Hematology & Oncology 2012 5:1
  7. Infantile hemangiomas (IH) are the most common benign tumors of infancy. The typical clinical course consists of rapid growth during the first year of life, followed by natural and gradual involution over a mu...

    Authors: Dan Xu, Teresa M O, Archil Shartava, Taylor C Fowles, Jianchang Yang, Louis M Fink, David C Ward, Martin C Mihm, Milton Waner and Yupo Ma
    Citation: Journal of Hematology & Oncology 2011 4:54
  8. Dabigatran is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity. It has been approved in the European Union and the United States of America for the prevention of thrombosis after...

    Authors: Santiago Redondo, Maria-Paz Martínez, Marta Ramajo, Jorge Navarro-Dorado, Abelardo Barez and Teresa Tejerina
    Citation: Journal of Hematology & Oncology 2011 4:53
  9. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells, but does not affect normal cells or human leukemic cells, such as MOLT-4 and U937 cells, which are rela...

    Authors: Benjawan Wudtiwai, Bungorn Sripanidkulchai, Prachya Kongtawelert and Ratana Banjerdpongchai
    Citation: Journal of Hematology & Oncology 2011 4:52
  10. Although the majority of published cases of lead poisoning come from occupational exposures, some traditional remedies may also contain toxic amounts of lead. Ayurveda is a system of traditional medicine that ...

    Authors: Krishna S Gunturu, Priyadharsini Nagarajan, Peter McPhedran, Thomas R Goodman, Michael E Hodsdon and Matthew P Strout
    Citation: Journal of Hematology & Oncology 2011 4:51
  11. Regulatory T cells (Tregs) are a specialized subpopulation of CD4+ T cells, which act to suppress the activation of other immune cells. Tregs represent important modulators for the interaction between lymphomas a...

    Authors: Jing Wang and Xiao-Yan Ke
    Citation: Journal of Hematology & Oncology 2011 4:50
  12. Most non-Hodgkin's lymphomas (NHL) initially respond to chemotherapy, but relapse is common and treatment is often limited by chemotherapy-related toxicity. Bortezomib, is a highly selective proteasome inhibit...

    Authors: Shiloh M Martin, Eric Churchill, Hayes McKnight, Christopher M Mahaffey, Yunpeng Ma, Robert T O'Donnell and Joseph M Tuscano
    Citation: Journal of Hematology & Oncology 2011 4:49
  13. Regulatory T cells (Treg) that express the transcription factor Foxp3 are enriched within a broad range of murine and human solid tumors. The ontogeny of these Foxp3 Tregs - selective accumulation or prolifera...

    Authors: Jon G Quatromoni, Lilah F Morris, Timothy R Donahue, Yue Wang, William McBride, Talal Chatila and James S Economou
    Citation: Journal of Hematology & Oncology 2011 4:48
  14. Light chain (AL) amyloidosis is a plasma cell dyscrasia characterized by the pathologic production of fibrillar proteins comprised of monoclonal light chains which deposit in tissues and cause organ dysfunctio...

    Authors: Michael Rosenzweig and Heather Landau
    Citation: Journal of Hematology & Oncology 2011 4:47
  15. The regimen of cytarabine, aclarubicin and G-CSF (CAG) has been widely used in China and Japan for treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We searched literature on CAG be...

    Authors: Guoqing Wei, Wanmao Ni, Jen-wei Chiao, Zhen Cai, He Huang and Delong Liu
    Citation: Journal of Hematology & Oncology 2011 4:46
  16. Acute megakaryoblastic leukemia (AMKL) is a type of acute myeloid leukemia (AML), in which majority of the blasts are megakaryoblastic. De novo AMKL in adulthood is rare, and carries very poor prognosis. We he...

    Authors: Xiao Min, Zhang Na, Liu Yanan and Li Chunrui
    Citation: Journal of Hematology & Oncology 2011 4:45
  17. Anti-platelet therapy plays an important role in the treatment of patients with thrombotic diseases. The most commonly used anti-platelet drugs, namely, aspirin, ticlopidine, and clopidogrel, are effective in ...

    Authors: Xuebin Ji and Ming Hou
    Citation: Journal of Hematology & Oncology 2011 4:44
  18. Idiopathic chronic neutropenia (ICN) describes a heterogeneous group of hematologic diseases characterized by low circulating neutrophil levels often associated with recurrent fevers, chronic mucosal inflammat...

    Authors: Roger M Lyons, Sharon T Wilks, Shelby Young and Gail L Brown
    Citation: Journal of Hematology & Oncology 2011 4:43
  19. The MRC UKALLXI trial tested the efficacy of different central nervous system (CNS) directed therapies in childhood acute lymphoblastic leukaemia (ALL). To evaluate morbidity 555/1826 randomised children under...

    Authors: Christina Halsey, Georgina Buck, Sue Richards, Faraneh Vargha-Khadem, Frank Hill and Brenda Gibson
    Citation: Journal of Hematology & Oncology 2011 4:42
  20. Ph- myeloproliferative neoplasms (MPNs) represent a heterogeneous group of chronic diseases characterized by increased expansion of hematopoietic cells of the myeloid lineage. JAK2V617F, an activation mutation...

    Authors: Anna H Zhao, Rufei Gao and Zhizhuang J Zhao
    Citation: Journal of Hematology & Oncology 2011 4:40
  21. A 54-year-old woman was diagnosed with infiltrative ductal breast carcinoma. Two years after treatment, the patient developed an acute myeloid leukemia (AML) which harbored del(11q23) in 8% of the blast cells....

    Authors: Hilda Rachel Diamond, Maria Helena Ornellas, Alberto Orfao, Bernadete E Gomes, Mércia M Campos, Teresa S Fernandez, Roberto I da Silva, Gilda Alves, Claudia Lage, Dayse A da Silva, Arthur Moellmann-Coelho, Geydson S da Cruz, Luis Fernando Bouzas and Eliana Abdelhay
    Citation: Journal of Hematology & Oncology 2011 4:39
  22. Sall4 is a key factor for the maintenance of pluripotency and self-renewal of embryonic stem cells (ESCs). Our previous studies have shown that Sall4 is a robust stimulator for human hematopoietic stem and pro...

    Authors: Jianchang Yang, Jerell R Aguila, Zaida Alipio, Raymond Lai, Louis M Fink and Yupo Ma
    Citation: Journal of Hematology & Oncology 2011 4:38
  23. The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of myeloma (MM) cells. This study identified that microRNA-15a and -16 expressions tightly correlated with prolifer...

    Authors: Mu Hao, Li Zhang, Gang An, Weiwei Sui, Zhen Yu, Dehui Zou, Yan Xu, Hong Chang and Lugui Qiu
    Citation: Journal of Hematology & Oncology 2011 4:37
  24. Bladder cancer occurs in the majority of cases in males. It represents the seventh most common cancer and the ninth most common cause of cancer deaths for men. Transitional cell carcinoma is the most predomina...

    Authors: Nabil Ismaili, Mounia Amzerin and Aude Flechon
    Citation: Journal of Hematology & Oncology 2011 4:35
  25. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with poor treatment outcomes. The aim of this study was to evaluate whether lymphopenia at...

    Authors: Yu Ri Kim, Jin Seok Kim, Soo Jeong Kim, Hyun Ae Jung, Seok Jin Kim, Won Seog Kim, Hye Won Lee, Hyeon Seok Eom, Seong Hyun Jeong, Joon Seong Park, June-Won Cheong and Yoo Hong Min
    Citation: Journal of Hematology & Oncology 2011 4:34
  26. The role of thymidylate synthase (TS) is essential as a key rate-limiting enzyme in DNA synthesis. It is the primary target of fluorouracil and its derivates in colorectal cancer. In this study, TS mRNA expres...

    Authors: Yanyan Liu, Qingxin Xia, Yanzhao Jia, Hongqiang Guo, Bing Wei, Yawei Hua and Shujun Yang
    Citation: Journal of Hematology & Oncology 2011 4:33
  27. Nilotinib is approved for treatment of newly diagnosed chronic myeloid leukemia (CML) and it is shown superiority over imatinib in first-line treatment for patients of CML. In this study, we established a nilo...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka and Kazuma Ohyashiki
    Citation: Journal of Hematology & Oncology 2011 4:32
  28. Pancreatic neuroendocrine tumors (NET) have diverse clinical presentations. Patients with symptoms of hormone secretion may require specific medical interventions to control those symptoms prior to antitumor i...

    Authors: Matthew H Kulke, Johanna Bendell, Larry Kvols, Joel Picus, Rodney Pommier and James Yao
    Citation: Journal of Hematology & Oncology 2011 4:29
  29. Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, and differentiation of neutrophilic granulocyte precursors, Recombinant G-CSF has been used for the treatment of congenital and ...

    Authors: Yongping Jiang, Wenhong Jiang, Yuchang Qiu and Wei Dai
    Citation: Journal of Hematology & Oncology 2011 4:28
  30. Hemangiopericytoma is a rare and aggressive meningeal tumor. Although surgical resection is the standard treatment, hemangiopericytomas often recur with high incidences of metastasis. The purpose of this study...

    Authors: Anand Veeravagu, Bowen Jiang, Chirag G Patil, Marco Lee, Scott G Soltys, Iris C Gibbs and Steven D Chang
    Citation: Journal of Hematology & Oncology 2011 4:26
  31. Although evaluation of at least 12 lymph nodes (LNs) is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate ...

    Authors: Chandrakumar Shanmugam, Robert B Hines, Nirag C Jhala, Venkat R Katkoori, Bin Zhang, James A Posey Jr, Harvey L Bumpers, William E Grizzle, Isam E Eltoum, Gene P Siegal and Upender Manne
    Citation: Journal of Hematology & Oncology 2011 4:25
  32. Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marro...

    Authors: Andrea L George, Pradeep Bangalore-Prakash, Shilpi Rajoria, Robert Suriano, Arulkumaran Shanmugam, Abraham Mittelman and Raj K Tiwari
    Citation: Journal of Hematology & Oncology 2011 4:24
  33. Downregulation of the B-cell chronic lymphocytic leukemia (CLL)/lymphoma11B (BCL11B) gene by small interfering RNA (siRNA) leads to growth inhibition and apoptosis of the human T-cell acute lymphoblastic leukemia...

    Authors: Xin Huang, Qi Shen, Si Chen, Shaohua Chen, Lijian Yang, Jianyu Weng, Xin Du, Piotr Grabarczyk, Grzegorz K Przybylski, Christian A Schmidt and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:23
  34. The matrix protein osteopontin has been shown to be a marker of osteoclastic activity in multiple myeloma patients, as well as a regulator of angiogenesis. We measured serum levels of osteopontin in 50 untreat...

    Authors: Aikaterini Sfiridaki, Spiros Miyakis, Constantina Pappa, George Tsirakis, Athanasios Alegakis, Vasileios Kotsis, Efstathios Stathopoulos and Michael Alexandrakis
    Citation: Journal of Hematology & Oncology 2011 4:22
  35. Recently, we clarified at the molecular level novel chromosomal translocation t(14;14)(q11;q32) in a case of Sézary syndrome, which caused a rearrangement from TRAJ7 to the PPP2R5C gene. PPP2R5C is one of the reg...

    Authors: Haitao Zheng, Yu Chen, Shaohua Chen, Yuzhe Niu, Lijian Yang, Bo Li, Yuhong Lu, Suxia Geng, Xin Du and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:21
  36. Differentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all trans-retinoic acid (ATRA); however, the mechanism regulating this process has not been fully characterized.

    Authors: Pan Jian, Zhao Wen Li, Tao Yan Fang, Wang Jian, Zhou Zhuan, Liao Xin Mei, Wu Shui Yan and Ni Jian
    Citation: Journal of Hematology & Oncology 2011 4:20
  37. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) leads to a prolonged state of immunodeficiency and requires reconstitution of normal T-cell immunity. Signal joint T-cell receptor excision DNA ci...

    Authors: Xiuli Wu, Kanger Zhu, Xin Du, Shaohua Chen, Lijian Yang, Jufeng Wu, Qifa Liu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2011 4:19
  38. We reviewed preclinical data and clinical development of MDM2 (murine double minute 2), ALK (anaplastic lymphoma kinase) and PARP (poly [ADP-ribose] polymerase) inhibitors. MDM2 binds to p53, and promotes degr...

    Authors: Yuan Yuan, Yu-Min Liao, Chung-Tsen Hsueh and Hamid R Mirshahidi
    Citation: Journal of Hematology & Oncology 2011 4:16
  39. Endometrial carcinoma is one of the most common gynecological malignancies in women. The diagnosis of the disease at early or premalignant stages is crucial for the patient's prognosis. To date, diagnosis and ...

    Authors: Yi-sheng Wang, Rui Cao, Hong Jin, Yi-ping Huang, Xiao-yan Zhang, Qing Cong, Yi-feng He and Cong-jian Xu
    Citation: Journal of Hematology & Oncology 2011 4:15
  40. The CyberKnife is an appealing delivery system for hypofractionated stereotactic body radiation therapy (SBRT) because of its ability to deliver highly conformal radiation therapy to moving targets. This confo...

    Authors: Eric K Oermann, Simeng Suy, Heather N Hanscom, Joy S Kim, Sue Lei, Xia Yu, Guowei Zhang, Brook Ennis, JoyAnn P Rohan, Nathaniel Piel, Benjamin A Sherer, Devin Borum, Viola J Chen, Gerald P Batipps, Nicholas L Constantinople, Stephen W Dejter…
    Citation: Journal of Hematology & Oncology 2011 4:12
  41. The objectives of the present study are to investigate the efficacy and safety profile of gemcitabine-based combinations in the treatment of locally advanced and metastatic pancreatic adenocarcinoma (LA/MPC).

    Authors: Jing Hu, Gang Zhao, Hong-Xia Wang, Lei Tang, Ying-Chun Xu, Yue Ma and Feng-Chun Zhang
    Citation: Journal of Hematology & Oncology 2011 4:11

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