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  1. There is increasing evidence of a constitutive activation of Akt in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and chemoresistance. Therefore, we evaluated the expression of phosph...

    Authors: Daniela Massihnia, Amir Avan, Niccola Funel, Mina Maftouh, Anne van Krieken, Carlotta Granchi, Rajiv Raktoe, Ugo Boggi, Babette Aicher, Filippo Minutolo, Antonio Russo, Leticia G. Leon, Godefridus J. Peters and Elisa Giovannetti
    Citation: Journal of Hematology & Oncology 2017 10:9
  2. Since the discovery of microRNAs (miRNAs) in the early 1990s, these small molecules have been increasingly recognized as key players in the regulation of critical biological processes. They have also been impl...

    Authors: John E.J. Rasko and Justin J.-L. Wong
    Citation: Journal of Hematology & Oncology 2017 10:8
  3. The difference in clinical features and treatment outcomes between localized sinonasal diffuse large B cell lymphoma (SN-DLBCL) and sinonasal extranodal NK/T cell lymphoma (SN-ENKTL) is unclear. Therefore, we ...

    Authors: Yu Huang, Bo Jia, Shiyu Jiang, Shengyu Zhou, Jianliang Yang, Peng Liu, Lin Gui, Xiaohui He, Yan Qin, Yan Sun and Yuankai Shi
    Citation: Journal of Hematology & Oncology 2017 10:7
  4. The X-linked inhibitor of apoptosis protein (XIAP) is a well-known potent apoptosis suppressor and also participates in cancer cell biological behaviors, therefore attracting great attentions as a potential an...

    Authors: Chao Huang, Xingruo Zeng, Guosong Jiang, Xin Liao, Claire Liu, Jingxia Li, Honglei Jin, Junlan Zhu, Hong Sun, Xue-Ru Wu and Chuanshu Huang
    Citation: Journal of Hematology & Oncology 2017 10:6
  5. Glioblastoma recurrence after treatment with the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab is characterized by a highly infiltrative and malignant behavior that renders surgical excis...

    Authors: Giovanni Luca Gravina, Andrea Mancini, Francesco Marampon, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Flora Vitale, Peter J. Richardson, Lee Patient, Stephen Burbidge and Claudio Festuccia
    Citation: Journal of Hematology & Oncology 2017 10:5
  6. Cholangiocarcinoma (CCA) is one of the most fatal malignant tumors with increasing incidence, mortality, and insensitivity to traditional chemo-radiotherapy and targeted therapy. Chimeric antigen receptor-modi...

    Authors: Kai-chao Feng, Ye-lei Guo, Yang Liu, Han-ren Dai, Yao Wang, Hai-yan Lv, Jian-hua Huang, Qing-ming Yang and Wei-dong Han
    Citation: Journal of Hematology & Oncology 2017 10:4
  7. Metastatic melanoma is an aggressive form of skin cancer with a high mortality rate and the fastest growing global incidence rate of all malignancies. The introduction of BRAF/MEK inhibitor combinations has yi...

    Authors: Adil Daud, Japinder Gill, Sheily Kamra, Lei Chen and Amit Ahuja
    Citation: Journal of Hematology & Oncology 2017 10:3
  8. Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show...

    Authors: Yeping Dong, Dan He, Zhenzi Peng, Wei Peng, Wenwen Shi, Jun Wang, Bin Li, Chunfang Zhang and Chaojun Duan
    Citation: Journal of Hematology & Oncology 2017 10:2
  9. Lung cancer continues to be the most common cause of cancer-related mortality worldwide. Recent advances in molecular diagnostics and immunotherapeutics have propelled the rapid development of novel treatment ...

    Authors: Bhagirathbhai Dholaria, William Hammond, Amanda Shreders and Yanyan Lou
    Citation: Journal of Hematology & Oncology 2016 9:138
  10. Pacritinib (SB1518) is a highly selective kinase inhibitor with specificity for JAK2, FLT3, IRAK1, and CFS1R. This multicenter phase 1/2 study evaluated the maximum tolerated dose (MTD), safety, and clinical a...

    Authors: Srdan Verstovsek, Olatoyosi Odenike, Jack W. Singer, Tanya Granston, Suliman Al-Fayoumi and H. Joachim Deeg
    Citation: Journal of Hematology & Oncology 2016 9:137
  11. Megakaryocytic cell maturation involves polyploidization, and megakaryocyte (MK) ploidy correlates with their maturation and platelet production. Retardation of MK maturation is closely associated with poor MK...

    Authors: Nick Huang, Mabel Lou, Hua Liu, Cecilia Avila and Yupo Ma
    Citation: Journal of Hematology & Oncology 2016 9:136
  12. Inappropriate activation of c-mesenchymal-epithelial transition (MET), the receptor tyrosine kinase (RTK) for hepatocyte growth factor (HGF), has been implicated in tumorigenesis and represented a promising th...

    Authors: Bao Quoc Lam, Lu Dai and Zhiqiang Qin
    Citation: Journal of Hematology & Oncology 2016 9:135
  13. Anti-cancer immune responses may contribute to the control of tumors after conventional chemotherapy, and different observations have indicated that chemotherapeutic agents can induce immune responses resultin...

    Authors: Maria Pia Abruzzese, Maria Teresa Bilotta, Cinzia Fionda, Alessandra Zingoni, Alessandra Soriani, Elisabetta Vulpis, Cristiana Borrelli, Beatrice Zitti, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Rosa Molfetta, Rossella Paolini, Angela Santoni and Marco Cippitelli
    Citation: Journal of Hematology & Oncology 2016 9:134
  14. Authors: George S. Laszlo, Todd A. Alonzo, Chelsea J. Gudgeon, Kimberly H. Harrington, Alex Kentsis, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Susana C. Raimondi, Betsy A. Hirsch, Alan S. Gamis, Soheil Meshinchi and Roland B. Walter
    Citation: Journal of Hematology & Oncology 2016 9:133

    The original article was published in Journal of Hematology & Oncology 2015 8:115

  15. Options for patients with relapsed or refractory (R/R) classical Hodgkin lymphoma (cHL) after brentuximab vedotin (Bv) and autologous stem cell transplantation (ASCT) are limited. Immune checkpoint inhibitors ...

    Authors: Lorenzo Falchi, Ahmed Sawas, Changchun Deng, Jennifer E. Amengual, Donald S. Colbourn, Emily A. Lichtenstein, Karen A. Khan, Lawrence H. Schwartz and Owen A. O’Connor
    Citation: Journal of Hematology & Oncology 2016 9:132
  16. Elderly patients with relapsed and refractory acute lymphoblastic leukemia (ALL) have poor prognosis. Autologous CD19 chimeric antigen receptor-modified T (CAR-T) cells have potentials to cure patients with B ...

    Authors: Bo Cai, Mei Guo, Yao Wang, Yajing Zhang, Jun Yang, Yelei Guo, Hanren Dai, Changlin Yu, Qiyun Sun, Jianhui Qiao, Kaixun Hu, Hongli Zuo, Zheng Dong, Zechuan Zhang, Mingxing Feng, Bingxia Li…
    Citation: Journal of Hematology & Oncology 2016 9:131
  17. As a well-characterized key player in various signal transduction networks, extracellular-signal-regulated kinase (ERK1/2) has been widely implicated in the development of many malignancies. We previously foun...

    Authors: Zeyou Wang, Qin Guo, Rong Wang, Gang Xu, Peiyao Li, Yingnan Sun, Xiaoling She, Qiang Liu, Qiong Chen, Zhibin Yu, Changhong Liu, Jing Xiong, Guiyuan Li and Minghua Wu
    Citation: Journal of Hematology & Oncology 2016 9:130
  18. Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML). Bcr-Abl-T315I mutation is th...

    Authors: Xiaoying Lan, Chong Zhao, Xin Chen, Peiquan Zhang, Dan Zang, Jinjie Wu, Jinghong Chen, Huidan Long, Li Yang, Hongbiao Huang, Bing Z. Carter, Xuejun Wang, Xianping Shi and Jinbao Liu
    Citation: Journal of Hematology & Oncology 2016 9:129
  19. Cancer cells show increased glycolysis and take advantage of this metabolic pathway to generate ATP. The TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits aerobic glycolysis and protects tumor c...

    Authors: Sixuan Qian, Jianyong Li, Ming Hong, Yu Zhu, Huihui Zhao, Yue Xie, Jiayu Huang, Yun Lian, Yanru Li, Shuai Wang, Jianping Mao and Yaoyu Chen
    Citation: Journal of Hematology & Oncology 2016 9:128
  20. Monoacylglycerol lipase (MAGL), a critical lipolytic enzyme, has emerged as a key regulator of tumor progression, yet its biological function and clinical significance in hepatocellular carcinoma (HCC) is stil...

    Authors: Weiping Zhu, Yiming Zhao, Jiamin Zhou, Xin Wang, Qi Pan, Ning Zhang, Longrong Wang, Miao Wang, Dihua Zhan, Zeyang Liu, Xigan He, Dening Ma, Shuang Liu and Lu Wang
    Citation: Journal of Hematology & Oncology 2016 9:127
  21. The aim of this study is to assess nucleoprotein expression of IKZF1/3 in patients with relapsed/refractory multiple myeloma (MM) who received lenalidomide-based therapy and correlated them with their clinical...

    Authors: Maryam Pourabdollah, Mohammad Bahmanyar, Eshetu G. Atenafu, Donna Reece, Jian Hou and Hong Chang
    Citation: Journal of Hematology & Oncology 2016 9:123
  22. Recent data have shown that γδ T cells can act as mediators for immune defense against tumors. Our previous study has demonstrated that persisting clonally expanded TRDV4 T cells might be relatively beneficial fo...

    Authors: Zhenyi Jin, Qiang Luo, Shuai Lu, Xinyu Wang, Zifan He, Jing Lai, Shaohua Chen, Lijian Yang, Xiuli Wu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2016 9:126
  23. Previous research suggested that single gene expression might be correlated with acute myeloid leukemia (AML) survival. Therefore, we conducted a systematical analysis for AML prognostic gene expressions.

    Authors: Hongmei Luo, Yu Qin, Frederic Reu, Sujuan Ye, Yang Dai, Jingcao Huang, Fangfang Wang, Dan Zhang, Ling Pan, Huanling Zhu, Yu Wu, Ting Niu, Zhijian Xiao, Yuhuan Zheng and Ting Liu
    Citation: Journal of Hematology & Oncology 2016 9:125
  24. CD274 (programmed death ligand 1, also known as B7H1) is expressed in both solid tumors and hematologic malignancies and is of critical importance for the escape of tumor cells from immune surveillance by inhi...

    Authors: Xia Fang, Chiqi Chen, Fangzhen Xia, Zhuo Yu, Yaping Zhang, Feifei Zhang, Hao Gu, Jiangbo Wan, Xiaocui Zhang, Wei Weng, Cheng Cheng Zhang, Guo-Qiang Chen, Aibing Liang, Li Xie and Junke Zheng
    Citation: Journal of Hematology & Oncology 2016 9:124
  25. Caspase-1 is present in the cytosol as an inactive zymogen and requires the protein complexes named “inflammasomes” for proteolytic activation. However, it remains unclear whether the proteolytic activity of c...

    Authors: Luqiao Wang, Hangfei Fu, Gayani Nanayakkara, Yafeng Li, Ying Shao, Candice Johnson, Jiali Cheng, William Y. Yang, Fan Yang, Muriel Lavallee, Yanjie Xu, Xiaoshu Cheng, Hang Xi, Jonathan Yi, Jun Yu, Eric T. Choi…
    Citation: Journal of Hematology & Oncology 2016 9:122
  26. Human T-cell leukemia virus type 1 (HTLV-1) infection is associated with adult T-cell leukemia/lymphoma (ATLL), a lymphoproliferative malignancy with a dismal prognosis and limited therapeutic options. Recent ...

    Authors: R. Moles, X. T. Bai, H. Chaib-Mezrag and C. Nicot
    Citation: Journal of Hematology & Oncology 2016 9:121
  27. We have previously described the existence of two phenotypically distinct cell subsets in ALK-positive anaplastic large cell lymphoma (ALK + ALCL) based on their differential responsiveness to a Sox2 reporter ...

    Authors: Chengsheng Wu, Hai-Feng Zhang, Nidhi Gupta, Abdulraheem Alshareef, Qian Wang, Yung-Hsing Huang, Jamie T. Lewis, Donna N. Douglas, Norman M. Kneteman and Raymond Lai
    Citation: Journal of Hematology & Oncology 2016 9:120
  28. The SIX family homeobox genes have been demonstrated to be involved in the tumor initiation and progression, but their clinicopathological features and prognostic values in non-small cell lung cancer (NSCLC) h...

    Authors: Qian Liu, Anping Li, Yijun Tian, Yu Liu, Tengfei Li, Cuntai Zhang, Jennifer D. Wu, Xinwei Han and Kongming Wu
    Citation: Journal of Hematology & Oncology 2016 9:119
  29. Myeloablative (MAC) and reduced-intensity conditioning (RIC) are established approaches for allogeneic stem cell transplantation (SCT) in acute myeloid leukemia (AML). Most deaths after MAC occur within the fi...

    Authors: Avichai Shimoni, Myriam Labopin, Bipin Savani, Liisa Volin, Gerhard Ehninger, Jurgen Kuball, Donald Bunjes, Nicolaas Schaap, Stephane Vigouroux, Andrea Bacigalupo, Hendrik Veelken, Jorge Sierra, Matthias Eder, Dietger Niederwieser, Mohamad Mohty and Arnon Nagler
    Citation: Journal of Hematology & Oncology 2016 9:118
  30. Long non-coding RNAs (lncRNAs) are known to play important roles in different cell contexts, including cancers. However, little is known about lncRNAs in cholangiocarcinoma (CCA), a cholangiocyte malignancy wi...

    Authors: Wen-Tao Wang, Hua Ye, Pan-Pan Wei, Bo-Wei Han, Bo He, Zhen- Hua Chen and Yue-Qin Chen
    Citation: Journal of Hematology & Oncology 2016 9:117
  31. Multiple myeloma is an incurable plasma cell malignancy that is mostly restricted to the bone marrow. Cancer-induced dysfunction of cytotoxic T cells at the tumor site may be responsible for immune evasion and...

    Authors: Claudia Zelle-Rieser, Shanmugapriya Thangavadivel, Rainer Biedermann, Andrea Brunner, Patrizia Stoitzner, Ella Willenbacher, Richard Greil and Karin Jöhrer
    Citation: Journal of Hematology & Oncology 2016 9:116
  32. Despite the considerable progress in understanding the molecular bases of acute myeloid leukemia (AML), new tools to link disease biology to the unpredictable patient clinical course are still needed. Herein, ...

    Authors: Matteo G. Carrabba, Laurette Tavel, Giacomo Oliveira, Alessandra Forcina, Giacomo Quilici, Francesca Nardelli, Cristina Tresoldi, Alessandro Ambrosi, Fabio Ciceri, Massimo Bernardi, Luca Vago and Giovanna Musco
    Citation: Journal of Hematology & Oncology 2016 9:115
  33. Although in recent years, the introduction of novel chemotherapy protocols has improved the outcome of T cell acute lymphoblastic leukemia (T-ALL) patients, refractory and/or relapsing disease remains a foremo...

    Authors: Annalisa Lonetti, Alessandra Cappellini, Alice Bertaina, Franco Locatelli, Andrea Pession, Francesca Buontempo, Camilla Evangelisti, Cecilia Evangelisti, Ester Orsini, Laura Zambonin, Luca Maria Neri, Alberto Maria Martelli and Francesca Chiarini
    Citation: Journal of Hematology & Oncology 2016 9:114
  34. Graft-versus-host disease (GvHD) remains the major obstacle to successful allogeneic hematopoietic stem cell transplantation, despite of the immunosuppressive regimens administered to control T cell alloreacti...

    Authors: Mª Carmen Herrero-Sánchez, Concepción Rodríguez-Serrano, Julia Almeida, Laura San Segundo, Susana Inogés, Ángel Santos-Briz, Jesús García-Briñón, Luis Antonio Corchete, Jesús F. San Miguel, Consuelo del Cañizo and Belén Blanco
    Citation: Journal of Hematology & Oncology 2016 9:113
  35. Endometrial carcinoma (EC) is one of the most common malignancies of the female reproductive system. Migration and invasion inhibitory protein (MIIP) gene was recently discovered candidate tumor suppress gene ...

    Authors: Yingmei Wang, Limei Hu, Ping Ji, Fei Teng, Wenyan Tian, Yuexin Liu, David Cogdell, Jinsong Liu, Anil K. Sood, Russell Broaddus, Fengxia Xue and Wei Zhang
    Citation: Journal of Hematology & Oncology 2016 9:112

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:163

  36. Monoclonal antibodies and small molecule tyrosine kinase inhibitors (TKIs) directed against the vascular endothelial growth factor (VEGF) or its receptors have been investigated in several studies for the trea...

    Authors: Jing Yu, Yue Zhang, Lai-Han Leung, Lian Liu, Fan Yang and Xiaojun Yao
    Citation: Journal of Hematology & Oncology 2016 9:111
  37. Authors: Cornel Joseph Phillip, Shadia Zaman, Shujun Shentu, Kumudha Balakrishnan, Jiexin Zhang, Veera Baladandayuthapani, Pietro Taverna, Sanjeev Redkar, Michael Wang, Christine Marie Stellrecht and Varsha Gandhi
    Citation: Journal of Hematology & Oncology 2016 9:110

    The original article was published in Journal of Hematology & Oncology 2013 6:92

  38. Natural killer/T-cell lymphoma (NKTCL) is an Epstein–Barr virus (EBV)-associated, highly aggressive lymphoma. Treatment outcome remains sub-optimal, especially for advanced-stage or relapsed diseases. Programm...

    Authors: Xi-wen Bi, Hua Wang, Wen-wen Zhang, Jing-hua Wang, Wen-jian Liu, Zhong-jun Xia, Hui-qiang Huang, Wen-qi Jiang, Yu-jing Zhang and Liang Wang
    Citation: Journal of Hematology & Oncology 2016 9:109
  39. A1 Proceedings of 2016 China Cancer Immunotherapy Workshop, Beijing, China

    Authors: Bin Xue, Jiaqi Xu, Wenru Song, Zhimin Yang, Ke Liu, Zihai Li, Zihai Li, Lieping Chen, Edward B. Garon, Siwen Hu-Lieskovan, Wei Ding, Chong-Xian Pan, Weijing Sun, Yong-Jun Liu, Lei Zheng, Delong Liu…
    Citation: Journal of Hematology & Oncology 2016 9(Suppl 1):104

    This article is part of a Supplement: Volume 9 Supplement 1

  40. Malignant gliomas are associated with a high mortality rate, and effective treatment options are limited. Thus, the development of novel targeted treatments to battle this deadly disease is imperative.

    Authors: Xuejiao Liu, Yulong Chong, Yiming Tu, Ning Liu, Chenglong Yue, Zhenglei Qi, Huize Liu, Yao Yao, Hongmei Liu, Shangfeng Gao, Mingshan Niu and Rutong Yu
    Citation: Journal of Hematology & Oncology 2016 9:108
  41. Allele-specific oligonucleotide real-time quantitative PCR (ASO-RQPCR) is a standardized technique for detection and monitoring of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) but not m...

    Authors: Yinlei Bai, Kwan Yeung Wong, Tsz Kin Fung and Chor Sang Chim
    Citation: Journal of Hematology & Oncology 2016 9:107
  42. DNMT3A mutations are frequently discovered in acute myeloid leukemia (AML), associated with poor outcome. Recently, a relapse case report of AML extramedullary disease has showed that ...

    Authors: Jie Xu, Wu Zhang, Xiao-Jing Yan, Xue-Qiu Lin, Wei Li, Jian-Qing Mi, Jun-Min Li, Jiang Zhu, Zhu Chen and Sai-Juan Chen
    Citation: Journal of Hematology & Oncology 2016 9:106
  43. Anlotinib is a novel multi-target tyrosine kinase inhibitor that is designed to primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret. We aimed to evaluate the safety, pharmacokinetics, and antitumor ...

    Authors: Yongkun Sun, Wei Niu, Feng Du, Chunxia Du, Shuting Li, Jinwan Wang, Li Li, Fengqing Wang, Yu Hao, Chuan Li and Yihebali Chi
    Citation: Journal of Hematology & Oncology 2016 9:105
  44. Authors: Gian Matteo Rigolin, Elena Saccenti, Cristian Bassi, Laura Lupini, Francesca Maria Quaglia, Maurizio Cavallari, Sara Martinelli, Luca Formigaro, Enrico Lista, Maria Antonella Bardi, Eleonora Volta, Elisa Tammiso, Aurora Melandri, Antonio Urso, Francesco Cavazzini, Massimo Negrini…
    Citation: Journal of Hematology & Oncology 2016 9:103

    The original article was published in Journal of Hematology & Oncology 2016 9:88

  45. The efficient generation of hematopoietic stem cells (HSCs) from human-induced pluripotent stem cells (iPSCs) holds great promise in personalized transplantation therapies. However, the derivation of functiona...

    Authors: Yulin Xu, Wei Shan, Xia Li, Binsheng Wang, Senquan Liu, Yebo Wang, Yan Long, Ruxiu Tie, Limengmeng Wang, Shuyang Cai, Hao Zhang, Yu Lin, Mingming Zhang, Weiyan Zheng, Yi Luo, Xiaohong Yu…
    Citation: Journal of Hematology & Oncology 2016 9:102
  46. Adoptive immunotherapy is gaining momentum to fight malignancies, whereby γδ T cells have received recent attention as an alternative cell source as to natural killer cells and αβ T cells. The advent of γδ T c...

    Authors: Heleen H. Van Acker, Sébastien Anguille, Yannick Willemen, Johan M. Van den Bergh, Zwi N. Berneman, Eva Lion, Evelien L. Smits and Viggo F. Van Tendeloo
    Citation: Journal of Hematology & Oncology 2016 9:101
  47. Glycosylation is the most complex post-translational modification of proteins. Altered glycans on the tumor- and host-cell surface and in the tumor microenvironment have been identified to mediate critical eve...

    Authors: Wan-Ling Ho, Wen-Ming Hsu, Min-Chuan Huang, Kenji Kadomatsu and Akira Nakagawara
    Citation: Journal of Hematology & Oncology 2016 9:100
  48. Long non-coding RNAs (lncRNAs) have been attracting immense research interests. The relevance of lncRNAs in biological and physiological as well as in pathological processes has increased along with the unders...

    Authors: Xinyu Tian, Jie Tian, Xinyi Tang, Jie Ma and Shengjun Wang
    Citation: Journal of Hematology & Oncology 2016 9:99
  49. Neuroblastoma is a relatively common and highly belligerent childhood tumor with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2-pyridylketone thiosemicarbazone series, ...

    Authors: Zhu-Ling Guo, Des R. Richardson, Danuta S. Kalinowski, Zaklina Kovacevic, Kian Cheng Tan-Un and Godfrey Chi-Fung Chan
    Citation: Journal of Hematology & Oncology 2016 9:98

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