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  1. Modulating immune inhibitory pathways has been a major recent breakthrough in cancer treatment. Checkpoint blockade antibodies targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programed cell-death prote...

    Authors: Weijie Ma, Barbara M. Gilligan, Jianda Yuan and Tianhong Li
    Citation: Journal of Hematology & Oncology 2016 9:47
  2. Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common onc...

    Authors: Lijuan Han, Claudia Schubert, Johanna Köhler, Mirle Schemionek, Susanne Isfort, Tim H. Brümmendorf, Steffen Koschmieder and Nicolas Chatain
    Citation: Journal of Hematology & Oncology 2016 9:45
  3. Long noncoding RNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) has been characterized as a critical factor in all-trans retinoic acid (ATRA)-induced differentiation of acute promyelocytic leukemia (APL) cel...

    Authors: Shuyong Wei, Ming Zhao, Xiaoling Wang, Yizhen Li and Kankan Wang
    Citation: Journal of Hematology & Oncology 2016 9:44
  4. In vitro culture of hematopoietic stem and progenitor cells (HPCs) is supported by a suitable cellular microenvironment, such as mesenchymal stromal cells (MSCs)—but MSCs are heterogeneous and poorly defined. ...

    Authors: Theresa Vasko, Joana Frobel, Richard Lubberich, Tamme W. Goecke and Wolfgang Wagner
    Citation: Journal of Hematology & Oncology 2016 9:43
  5. In tumor microenvironment, a continuous cross-talk between cancer cells and other cellular components is required to sustain tumor progression. Accumulating evidence suggests that exosomes, a novel way of cell...

    Authors: Xiaoxia Li, Shihua Wang, Rongjia Zhu, Hongling Li, Qin Han and Robert Chunhua Zhao
    Citation: Journal of Hematology & Oncology 2016 9:42
  6. Aggressive nature killer cell leukemia (ANKL) is a mature NK-T cell lymphoma with worse prognosis, but optimal treatment is unclear. Therefore, we analyzed the efficacy of l-asparaginase-based regimens for ANKL p...

    Authors: Ki Sun Jung, Su-Hee Cho, Seok Jin Kim, Young Hyeh Ko, Eun-Suk Kang and Won Seog Kim
    Citation: Journal of Hematology & Oncology 2016 9:41
  7. Frequency relapses are common in Philadelphia chromosome-positive (Ph-positive) acute lymphoblastic leukemia (ALL) following tyrosine kinase inhibitors (TKIs). CDKN2A/B is believed to contribute to this chemot...

    Authors: Na Xu, Yu-ling Li, Xuan Li, Xuan Zhou, Rui Cao, Huan Li, Lin Li, Zi-yuan Lu, Ji-xian Huang, Zhi-ping Fan, Fen Huang, Hong-sheng Zhou, Song Zhang, Zhi Liu, Hong-qian Zhu, Qi-fa Liu…
    Citation: Journal of Hematology & Oncology 2016 9:40
  8. The MDS-IWG and NCCN currently endorse both FAB and WHO classifications of MDS and AML, thus allowing patients with 20–30 % bone marrow blasts (AML20–30, formerly MDS-RAEB-t) to be categorised and treated as e...

    Authors: Lisa Pleyer, Sonja Burgstaller, Reinhard Stauder, Michael Girschikofsky, Heinz Sill, Konstantin Schlick, Josef Thaler, Britta Halter, Sigrid Machherndl-Spandl, Armin Zebisch, Angelika Pichler, Michael Pfeilstöcker, Eva-Maria Autzinger, Alois Lang, Klaus Geissler, Daniela Voskova…
    Citation: Journal of Hematology & Oncology 2016 9:39
  9. There is no consensus regarding optimal treatment for peripheral T-cell lymphomas (PTCL), especially in relapsed or refractory cases, which have very poor prognosis and a dismal outcome, with 5-year overall su...

    Authors: Cinzia Pellegrini, Anna Dodero, Annalisa Chiappella, Federico Monaco, Debora Degl’Innocenti, Flavia Salvi, Umberto Vitolo, Lisa Argnani, Paolo Corradini and Pier Luigi Zinzani
    Citation: Journal of Hematology & Oncology 2016 9:38
  10. Peripheral T cell lymphoma (PTCL) is a rare and heterogeneous group of non-Hodgkin lymphomas with a very poor prognosis. The standard first-line treatments have resulted in unsatisfactory patient outcomes. Wit...

    Authors: Yaping Zhang, Wei Xu, Hong Liu and Jianyong Li
    Citation: Journal of Hematology & Oncology 2016 9:37
  11. The constitutive hyper-activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways has frequently been associated with acute myeloid leukem...

    Authors: Yanan Gao, Juan Gao, Minghao Li, Yawei Zheng, Yajie Wang, Hongyan Zhang, Weili Wang, Yajing Chu, Xiaomin Wang, Mingjiang Xu, Tao Cheng, Zhenyu Ju and Weiping Yuan
    Citation: Journal of Hematology & Oncology 2016 9:36
  12. In haploidentical stem cell transplantations (haplo-SCT), nearly all patients have more than one donor. A key issue in the haplo-SCT setting is the search for the best donor, because donor selection can signif...

    Authors: Ying-Jun Chang, Leo Luznik, Ephraim J. Fuchs and Xiao-Jun Huang
    Citation: Journal of Hematology & Oncology 2016 9:35
  13. Recent studies indicate that angiogenesis is important in the pathogenesis of acute myeloid leukemias (AMLs). Among the various AMLs, the bone marrow angiogenetic response is particularly pronounced in acute p...

    Authors: Ernestina Saulle, Alessia Petronelli, Elvira Pelosi, Elena Coppotelli, Luca Pasquini, Ramona Ilari, Francesco Lo-Coco and Ugo Testa
    Citation: Journal of Hematology & Oncology 2016 9:33
  14. A previous study has demonstrated a significantly increased CD3ζ gene expression level in aplastic anemia (AA). However, the mechanism underlying the upregulated CD3ζ mRNA expression level and that of T cell a...

    Authors: Bo Li, Lixing Guo, Yuping Zhang, Yankai Xiao, Mingjuan Wu, Lingling Zhou, Shaohua Chen, Lijian Yang, Xiang Lu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2016 9:32
  15. Hematologic malignancies arising in the setting of established germ cell tumors have been previously described and have a dismal prognosis. Identification of targetable mutations and pathway dysregulation thro...

    Authors: Jessica T. Leonard, Philipp W. Raess, Jennifer Dunlap, Brandon Hayes-Lattin, Jeffrey W. Tyner and Elie Traer
    Citation: Journal of Hematology & Oncology 2016 9:31
  16. The t(11;14) translocation resulting in constitutive cyclin D1 expression is an early event in mantle cell lymphoma (MCL) transformation. Patients with a highly proliferative phenotype produce cyclin D1 transc...

    Authors: Chioniso Patience Masamha, Todd R. Albrecht and Eric J. Wagner
    Citation: Journal of Hematology & Oncology 2016 9:30
  17. Anti-programmed death-1 therapy has poor efficacy in mismatch repair-proficient (pMMR) colorectal cancers; however, its efficacy in pMMR gastric cancers remains undetermined. Here, we report the case of a pati...

    Authors: Kuo-Hsing Chen, Chang-Tsu Yuan, Li-Hui Tseng, Chia-Tung Shun and Kun-Huei Yeh
    Citation: Journal of Hematology & Oncology 2016 9:29
  18. Recent population-based studies in the United States of America (USA) and other countries have shown improvements in survival for patients with chronic lymphocytic leukemia (CLL) diagnosed in the early twenty-...

    Authors: Dianne Pulte, Felipe A. Castro, Lina Jansen, Sabine Luttmann, Bernd Holleczek, Alice Nennecke, Meike Ressing, Alexander Katalinic and Hermann Brenner
    Citation: Journal of Hematology & Oncology 2016 9:28
  19. Juvenile myelomonocytic leukemia (JMML) is a fatal, myelodysplastic/myeloproliferative neoplasm of early childhood. Patients with JMML have mutually exclusive genetic abnormalities in granulocyte-macrophage co...

    Authors: Yozo Nakazawa, Kazuyuki Matsuda, Takashi Kurata, Akane Sueki, Miyuki Tanaka, Kazuo Sakashita, Chihaya Imai, Matthew H. Wilson and Kenichi Koike
    Citation: Journal of Hematology & Oncology 2016 9:27
  20. Interim positron emission tomography after 2 cycles of ABVD (iPET-2) is a good predictor of outcome in advanced-stage classic Hodgkin lymphoma. So far, there are no other prognostic biomarkers capable of ident...

    Authors: Giorgio La Nasa, Marianna Greco, Roberto Littera, Sara Oppi, Ivana Celeghini, Rossella Caria, Sara Lai, Rita Porcella, Massimo Martino, Alessandra Romano, Francesco Di Raimondo, Andrea Gallamini, Carlo Carcassi and Giovanni Caocci
    Citation: Journal of Hematology & Oncology 2016 9:26
  21. Increasing numbers of patients are receiving haplo-identical stem cell transplantation (haplo-SCT) for treatment of acute leukemia with reduced intensity (RIC) or myeloablative (MAC) conditioning regimens. The...

    Authors: Marie T. Rubio, Bipin N. Savani, Myriam Labopin, Simona Piemontese, Emmanuelle Polge, Fabio Ciceri, Andrea Bacigalupo, William Arcese, Yener Koc, Dietrich Beelen, Zafer Gülbas, Depei Wu, Stella Santarone, Johanna Tischer, Boris Afanasyev, Christoph Schmid…
    Citation: Journal of Hematology & Oncology 2016 9:25
  22. Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a dru...

    Authors: Zizhen Feng, Yuan Yao, Chao Zhou, Fengju Chen, Fangrui Wu, Liping Wei, Wei Liu, Shuo Dong, Michele Redell, Qianxing Mo and Yongcheng Song
    Citation: Journal of Hematology & Oncology 2016 9:24
  23. ASP3026 is a second-generation anaplastic lymphoma kinase (ALK) inhibitor that has potent in vitro activity against crizotinib-resistant ALK-positive tumors. This open-label, multicenter, first-in-human phase I s...

    Authors: Tianhong Li, Patricia LoRusso, Michael L. Maitland, Sai-Hong Ignatius Ou, Erkut Bahceci, Howard A. Ball, Jung Wook Park, Geoffrey Yuen and Anthony Tolcher
    Citation: Journal of Hematology & Oncology 2016 9:23
  24. Achievement of durable responses in patients with relapsed/refractory peripheral T cell lymphoma (PTCL) is challenging with current therapies, and there are few data regarding the potential benefits of continu...

    Authors: Francine Foss, Steven Horwitz, Barbara Pro, H. Miles Prince, Lubomir Sokol, Barbara Balser, Julie Wolfson and Bertrand Coiffier
    Citation: Journal of Hematology & Oncology 2016 9:22

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:154

  25. Sorafenib is recognized as a standard treatment for advanced hepatocellular carcinoma (HCC). However, many patients have to adopt dose reduction or terminate the use of sorafenib because of side effects. In ad...

    Authors: Abin You, Manqing Cao, Zhigui Guo, Bingfeng Zuo, Junrong Gao, Hongyuan Zhou, Huikai Li, Yunlong Cui, Feng Fang, Wei Zhang, Tianqiang Song, Qiang Li, Xiaolin Zhu, Haifang Yin, Huichuan Sun and Ti Zhang
    Citation: Journal of Hematology & Oncology 2016 9:20
  26. Patients with Ph-negative myeloproliferative neoplasms (MPN), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are at increased risk for thrombosis/thromboemboli...

    Authors: A. Kaifie, M. Kirschner, D. Wolf, C. Maintz, M. Hänel, N. Gattermann, E. Gökkurt, U. Platzbecker, W. Hollburg, J. R. Göthert, S. Parmentier, F. Lang, R. Hansen, S. Isfort, K. Schmitt, E. Jost…
    Citation: Journal of Hematology & Oncology 2016 9:18
  27. The polycomb complex protein BMI-1 (BMI-1) is a putative oncogene reported to be overexpressed in multiple myeloma (MM). Silencing of BMI-1 was shown to impair the growth and survival of MM cells. However, the...

    Authors: Arnold Bolomsky, Karin Schlangen, Wolfgang Schreiner, Niklas Zojer and Heinz Ludwig
    Citation: Journal of Hematology & Oncology 2016 9:17
  28. Non-small cell lung cancer (NSCLC) causes considerable mortality in the world. Owing to molecular biological progress, treatments in adenocarcinoma have evolved revolutionarily while those in squamous lung can...

    Authors: Yijun Tian, Qian Liu, Xuelian He, Xun Yuan, Yuan Chen, Qian Chu and Kongming Wu
    Citation: Journal of Hematology & Oncology 2016 9:14
  29. Our previous pilot studies aimed to examine the role of hydrogen sulfide (H2S) in the generation of endothelial progenitor cells led to an unexpected result, i.e., H2S promoted the differentiation of certain hema...

    Authors: Huan-Di Liu, Ai-Jie Zhang, Jing-Jing Xu, Ying Chen and Yi-Chun Zhu
    Citation: Journal of Hematology & Oncology 2016 9:13
  30. Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells in both children and adults. Although improvements in contemporary therapy and development of new treatment s...

    Authors: Pei-Jie Shi, Lu-Hong Xu, Kang-Yu Lin, Wen-jun Weng and Jian-Pei Fang
    Citation: Journal of Hematology & Oncology 2016 9:12
  31. Cancer is currently one of the leading causes of death worldwide and is one of the most challenging major public health problems. The main challenges faced by clinicians in the management and treatment of canc...

    Authors: Zhenbo Tu, Ruijing Xiao, Jie Xiong, Kingsley M. Tembo, Xinzhou Deng, Meng Xiong, Pan Liu, Meng Wang and Qiuping Zhang
    Citation: Journal of Hematology & Oncology 2016 9:10
  32. We herein report the first case of X-linked agammaglobulinemia (XLA) that underwent allogeneic stem cell transplantation using reduced intensity conditioning (RIC). We chronologically observed the reconstituti...

    Authors: Kazuhiro Ikegame, Kohsuke Imai, Motoi Yamashita, Akihiro Hoshino, Hirokazu Kanegane, Tomohiro Morio, Katsuji Kaida, Takayuki Inoue, Toshihiro Soma, Hiroya Tamaki, Masaya Okada and Hiroyasu Ogawa
    Citation: Journal of Hematology & Oncology 2016 9:9
  33. Cancer-associated fibroblasts (CAFs) are believed to play an essential role in cancer initiation and development. However, little research has been undertaken to evaluate the role of CAFs in endometrial cancer...

    Authors: Fei Teng, Wen-Yan Tian, Ying-Mei Wang, Yan-Fang Zhang, Fei Guo, Jing Zhao, Chao Gao and Feng-Xia Xue
    Citation: Journal of Hematology & Oncology 2016 9:8
  34. Advanced pancreatic cancer (PC) has very poor prognosis with present treatments, thus necessitating continued efforts to find improved therapeutic approaches. Both preclinical and preliminary clinical data ind...

    Authors: Zibing Wang, Yuqing Liu, Rui’e Li, Yiman Shang, Yong Zhang, Lingdi Zhao, Wei Li, Yonghao Yang, Xiaojie Zhang, Tiejun Yang, Changfu Nie, Feng Han, Ying Liu, Suxia Luo, Quanli Gao and Yongping Song
    Citation: Journal of Hematology & Oncology 2016 9:6
  35. In spite of the recent discovery of genetic mutations in most myelodysplasic (MDS) patients, the pathophysiology of these disorders still remains poorly understood, and only few in vivo models are available to...

    Authors: Laura Guerenne, Stéphanie Beurlet, Mohamed Said, Petra Gorombei, Carole Le Pogam, Fabien Guidez, Pierre de la Grange, Nader Omidvar, Valérie Vanneaux, Ken Mills, Ghulam J Mufti, Laure Sarda-Mantel, Maria Elena Noguera, Marika Pla, Pierre Fenaux, Rose Ann Padua…
    Citation: Journal of Hematology & Oncology 2016 9:5
  36. Bone marrow (BM) niches are often inaccessible for controlled experimentation due to their difficult accessibility, biological complexity, and three-dimensional (3D) geometry.

    Authors: Mónica S. Ventura Ferreira, Christian Bergmann, Isabelle Bodensiek, Kristina Peukert, Jessica Abert, Rafael Kramann, Paul Kachel, Björn Rath, Stephan Rütten, Ruth Knuchel, Benjamin L. Ebert, Horst Fischer, Tim H. Brümmendorf and Rebekka K. Schneider
    Citation: Journal of Hematology & Oncology 2016 9:4
  37. Hypoacetylation on histone H3 of human prostate cancer cells has been described. Little is known about the modifications of other histones from prostate cancer cells.

    Authors: Shundong Cang, Xiaobin Xu, Yuehua Ma, Delong Liu and J. W. Chiao
    Citation: Journal of Hematology & Oncology 2016 9:3
  38. Activated B lymphocytes harbor programmed DNA double-strand breaks (DSBs) initiated by activation-induced deaminase (AID) and repaired by non-homologous end-joining (NHEJ). While it has been proposed that thes...

    Authors: Zhangguo Chen, Mihret T. Elos, Sawanee S. Viboolsittiseri, Katherine Gowan, Sonia M. Leach, Michael Rice, Maxwell D. Eder, Kenneth Jones and Jing H. Wang
    Citation: Journal of Hematology & Oncology 2016 9:2
  39. Our previous study reported that microRNA-26a (miR-26a) inhibited tumor progression by inhibiting tumor angiogenesis and intratumoral macrophage infiltration in hepatocellular carcinoma (HCC). The direct roles...

    Authors: De-Ning Ma, Zong-Tao Chai, Xiao-Dong Zhu, Ning Zhang, Di-Hua Zhan, Bo-Gen Ye, Cheng-Hao Wang, Cheng-Dong Qin, Yi-Ming Zhao, Wei-Ping Zhu, Man-Qing Cao, Dong-Mei Gao, Hui-Chuan Sun and Zhao-You Tang
    Citation: Journal of Hematology & Oncology 2016 9:1
  40. We have previously shown that palmitoylation is essential for NRAS leukemogenesis, suggesting that targeting RAS palmitoylation may be an effective therapy for NRAS-related cancers. For KRAS-driven cancer, alt...

    Authors: Huanbin Zhao, Ping Liu, Ruihong Zhang, Min Wu, Donghe Li, Xuemei Zhao, Chun Zhang, Bo Jiao, Bing Chen, Zhu Chen and Ruibao Ren
    Citation: Journal of Hematology & Oncology 2015 8:132
  41. Bispecific antibodies (BsAbs) recognize two different epitopes. This dual specificity opens up a wide range of applications, including redirecting T cells to tumor cells, blocking two different signaling pathw...

    Authors: Gaowei Fan, Zujian Wang, Mingju Hao and Jinming Li
    Citation: Journal of Hematology & Oncology 2015 8:130

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