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  1. Defects in filamin A (FLNA) gene could lead to low platelet counts and decreased surface expression of glycoprotein (GP) Ibα. Here, we report and investigate the FLNA genomic alteration of a case with Bernard-...

    Authors: Jiaming Li, KeSheng Dai, Zhaoyue Wang, Lijuan Cao, Xia Bai and Changgeng Ruan
    Citation: Journal of Hematology & Oncology 2015 8:79
  2. Severe aplastic anemia (SAA) is a rare disorder leading to bone marrow failure, which if left untreated, is invariably fatal. Conventional therapies with immunosuppressive therapy or allogeneic hematopoietic s...

    Authors: P. T. Vo, J. Pantin, C. Ramos, L. Cook, E. Cho, R. Kurlander, H. Khuu, J. Barrett, S. Leitman and R. W. Childs
    Citation: Journal of Hematology & Oncology 2015 8:78
  3. Multiple myeloma (MM) is a hematologic malignancy that is characterized by the proliferation of abnormal bone marrow plasma cells (BMPC) and overproduction of immunoglobulin or light chains with evidence of en...

    Authors: Saurabh Chhabra, Sandeep Jain, Caroline Wallace, Feng Hong and Bei Liu
    Citation: Journal of Hematology & Oncology 2015 8:77
  4. To validate its efficacy in the context of the human immune system, a novel therapeutic vaccine of hGM-CSF/hTNFα surface-modified PC-3 cells against human prostate cancer was evaluated in the human peripheral ...

    Authors: Shouhua Lai, Zhiyong Huang, Yunting Guo, Yunqin Cui, Lei Wang, Weifeng Ren, Furong Ying, Hui Gao, Lingxia He, Tieli Zhou, Jiegen Jiang and Jimin Gao
    Citation: Journal of Hematology & Oncology 2015 8:76
  5. Circulating tumor cells (CTCs) are cells shed from tumors or metastatic sites and are a potential biomarker for cancer diagnosis, management, and prognostication. The majority of current studies use single or ...

    Authors: Sai Mun Leong, Karen ML Tan, Hui Wen Chua, Doreen Tan, Delly Fareda, Saabry Osmany, Mo-Huang Li, Steven Tucker and Evelyn SC Koay
    Citation: Journal of Hematology & Oncology 2015 8:75
  6. The prognostic importance of extramedullary involvement in patients with Waldenström macroglobulinemia (WM) at diagnosis and treatment options for these patients has not been well evaluated. In this study, we ...

    Authors: Xin Cao, Qing Ye, Robert Z. Orlowski, Xiaoxiao Wang, Sanam Loghavi, Meifeng Tu, Sheeba K. Thomas, Jatin Shan, Shaoying Li, Muzaffar Qazilbash, C. Cameron Yin, Donna Weber, Roberto N. Miranda, Zijun Y. Xu-Monette, L. Jeffrey Medeiros and Ken H. Young
    Citation: Journal of Hematology & Oncology 2015 8:74
  7. We identified three novel mutations (p.Gly39Arg, p.Lys157Glu, p.Cys379Gly) and one previously known mutation (p.Asp141Asn) in the von Willebrand factor propeptide from three von Willebrand disease patients. Al...

    Authors: Jie Yin, Zhenni Ma, Jian Su, Jiong-Wei Wang, Xiaojuan Zhao, Jing Ling, Xia Bai, Wanyan Ouyang, Zhaoyue Wang, Ziqiang Yu and Changgeng Ruan
    Citation: Journal of Hematology & Oncology 2015 8:73
  8. Previous studies indicated that upregulating TCRζ partially recovers T cell function in patients with leukemia. In this study, we characterized the cytokine profile of TCRζ-transfected T cells from acute myeloid ...

    Authors: Shaohua Chen, Xianfeng Zha, Li Shi, Lingling Zhou, Lijian Yang, Bo Li, Xiuli Wu, Jun Zhong, Tao Zhang, Yuhong Lu, Kanger Zhu and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2015 8:72
  9. Increased plasma levels of proteasome have been associated with various neoplasms, especially myeloid malignancies. Little is known of the cellular origin and release mechanisms of such proteasome. We recently...

    Authors: Alessandro Pecci, Vittorio Necchi, Serena Barozzi, Agostina Vitali, Emanuela Boveri, Chiara Elena, Paolo Bernasconi, Patrizia Noris and Enrico Solcia
    Citation: Journal of Hematology & Oncology 2015 8:71
  10. The prognostic role of tumor-related parameters in diffuse large B cell lymphoma (DLBCL) is a matter of controversy.

    Authors: Alexandar Tzankov, Nora Leu, Simone Muenst, Darius Juskevicius, Dirk Klingbiel, Christoph Mamot and Stephan Dirnhofer
    Citation: Journal of Hematology & Oncology 2015 8:70
  11. The genomic landscape of children with acute myeloid leukemia (AML) who do not carry any cytogenetic abnormality (CN-AML) is particularly heterogeneous and challenging, being characterized by different clinica...

    Authors: Marco Togni, Riccardo Masetti, Martina Pigazzi, Annalisa Astolfi, Daniele Zama, Valentina Indio, Salvatore Serravalle, Elena Manara, Valeria Bisio, Carmelo Rizzari, Giuseppe Basso, Andrea Pession and Franco Locatelli
    Citation: Journal of Hematology & Oncology 2015 8:69
  12. MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate...

    Authors: Srivatsava Naidu, Peter Magee and Michela Garofalo
    Citation: Journal of Hematology & Oncology 2015 8:68
  13. SUMO-activating enzyme subunit 2 (SAE2) is the sole E1-activating enzyme required for numerous important protein SUMOylation, abnormal of which is associated with carcinogenesis. SAE2 inactivation was recently...

    Authors: Xiaoke Liu, Yong Xu, Zongguo Pang, Fuchun Guo, Qing Qin, Tao Yin, Yaxiong Sang, Chengjun Feng, Xiaoyu Li, Li Jiang, Pei Shu and Yongsheng Wang
    Citation: Journal of Hematology & Oncology 2015 8:67
  14. Recurrent, metastatic mesenchymal myxoid tumors of the gynecologic tract present a management challenge as there is minimal evidence to guide systemic therapy. Such tumors also present a diagnostic dilemma, as...

    Authors: Vivek Subbiah, Caitlin McMahon, Shreyaskumar Patel, Ralph Zinner, Elvio G Silva, Julia A. Elvin, Ishwaria M. Subbiah, Chimela Ohaji, Dhakshina Moorthy Ganeshan, Deepa Anand, Charles F. Levenback, Jenny Berry, Tim Brennan, Juliann Chmielecki, Zachary R. Chalmers, John Mayfield…
    Citation: Journal of Hematology & Oncology 2015 8:66
  15. Plasmablastic lymphoma (PBL) is a rare aggressive neoplasm with lymphoid and plasmacytic differentiation that is commonly associated with immunodeficiency and an unfavorable prognosis. Clinicopathologic featur...

    Authors: Sanam Loghavi, Khaled Alayed, Tariq N. Aladily, Zhuang Zuo, Siok-Bian Ng, Guilin Tang, Shimin Hu, C. Cameron Yin, Roberto N. Miranda, L. Jeffrey Medeiros and Joseph D. Khoury
    Citation: Journal of Hematology & Oncology 2015 8:65
  16. Upon inflammation, myeloid cell generation in the bone marrow (BM) is broadly enhanced by the action of induced cytokines which are produced locally and at multiple sites throughout the body.

    Authors: Anne Schumacher, Bernd Denecke, Till Braunschweig, Jasmin Stahlschmidt, Susanne Ziegler, Lars-Ove Brandenburg, Matthias B. Stope, Antons Martincuks, Michael Vogt, Dieter Görtz, Annalisa Camporeale, Valeria Poli, Gerhard Müller-Newen, Tim H. Brümmendorf and Patrick Ziegler
    Citation: Journal of Hematology & Oncology 2015 8:64
  17. Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin’s lymphoma. Despite initial intense chemotherapy, up to 50 % of cases of MCL relapse often in a chemoresistant form. We hypothesize...

    Authors: Rohit Mathur, Lalit Sehgal, Frank K. Braun, Zuzana Berkova, Jorge Romaguerra, Michael Wang, M. Alma Rodriguez, Luis Fayad, Sattva S. Neelapu and Felipe Samaniego
    Citation: Journal of Hematology & Oncology 2015 8:63
  18. Interaction of integrin β3 with c-Src plays critical roles in cellular signaling which is heavily implicated in platelet adhesion and aggregation, as well as in tumor cell proliferation and metastasis or in os...

    Authors: Jiansong Huang, Xiaofeng Shi, Wenda Xi, Ping Liu, Zhangbiao Long and Xiaodong Xi
    Citation: Journal of Hematology & Oncology 2015 8:62
  19. Methotrexate (MTX) eradicates leukemic cells by disrupting de novo nucleotide biosynthesis and DNA replication, resulting in cell death. Since its introduction in 1947, MTX-containing chemotherapeutic regimens...

    Authors: Anna Wojtuszkiewicz, Godefridus J. Peters, Nicole L. van Woerden, Boas Dubbelman, Gabriele Escherich, Kjeld Schmiegelow, Edwin Sonneveld, Rob Pieters, Peter M. van de Ven, Gerrit Jansen, Yehuda G. Assaraf, Gertjan J. L. Kaspers and Jacqueline Cloos
    Citation: Journal of Hematology & Oncology 2015 8:61
  20. Tyrosine kinase inhibitors (TKIs) targeting signaling molecules downstream B cell receptor (BCR) are powerfully spreading in the therapeutic landscape of B cell lymphoproliferative disease, due to a manageable...

    Authors: Rossana Maffei, Stefania Fiorcari, Silvia Martinelli, Leonardo Potenza, Mario Luppi and Roberto Marasca
    Citation: Journal of Hematology & Oncology 2015 8:60
  21. The mouse is an organism that is widely used as a mammalian model for studying human physiology or disease, and the development of immunodeficient mice has provided a valuable tool for basic and applied human ...

    Authors: Wei Ye, Zhiwu Jiang, Guan-Xiong Li, Yiren Xiao, Simiao Lin, Yunxin Lai, Suna Wang, Baiheng Li, Bei Jia, Yin Li, Zhi-liang Huang, Jin Li, Fenglan Feng, Shuhua Li, Huihui Yao, Zixia Liu…
    Citation: Journal of Hematology & Oncology 2015 8:59
  22. Biliary cancers are highly aggressive tumors that are often diagnosed an advanced disease stage and have a poor outcome with systemic therapy. Recent efforts towards molecular characterization have identified ...

    Authors: Milind Javle, Chaitanya Churi, HyunSeon C. Kang, Rachna Shroff, Filip Janku, Rakesh Surapaneni, Mingxin Zuo, Christian Barrera, Humaid Alshamsi, Sunil Krishnan, Lopa Mishra, Robert A. Wolff, Ahmed O. Kaseb, Melanie B. Thomas and Abby B. Siegel
    Citation: Journal of Hematology & Oncology 2015 8:58
  23. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death, especially in China. And the mechanism of its progression remains poorly understood. Growing evidence indicates that long no...

    Authors: Ming-de Huang, Wen-ming Chen, Fu-zhen Qi, Rui Xia, Ming Sun, Tong-peng Xu, Li Yin, Er-bao Zhang, Wei De and Yong-qian Shu
    Citation: Journal of Hematology & Oncology 2015 8:57

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:143

  24. microRNAs (miRNAs) have been reported to modulate macrophage colony-stimulating factor (M-CSF) and macrophages. The aim of this study was to find whether miR-26a can suppress M-CSF expression and the recruitme...

    Authors: Zong-Tao Chai, Xiao-Dong Zhu, Jian-Yang Ao, Wen-Quan Wang, Dong-Mei Gao, Jian Kong, Ning Zhang, Yuan-Yuan Zhang, Bo-Gen Ye, De-Ning Ma, Hao Cai and Hui-Chuan Sun
    Citation: Journal of Hematology & Oncology 2015 8:56
  25. Congenital sideroblastic anemias (CSAs) comprise a group of heterogenous genetic diseases that are caused by the mutation of various genes involved in heme biosynthesis, iron-sulfur cluster biogenesis, or mito...

    Authors: Wenbin An, Jingliao Zhang, Lixian Chang, Yingchi Zhang, Yang Wan, Yuanyuan Ren, Deyun Niu, Jian Wu, Xiaofan Zhu and Ye Guo
    Citation: Journal of Hematology & Oncology 2015 8:55
  26. Neoadjuvant erlotinib and customized adjuvant therapy are appealing but controversial. The purpose of this study was to evaluate the role of biomarker-guided neoadjuvant treatment strategy in patients with III...

    Authors: Wenzhao Zhong, Xuening Yang, Honghong Yan, Xuchao Zhang, Jian Su, Zhihong Chen, Riqiang Liao, Qiang Nie, Song Dong, Qing Zhou, Jinji Yang, Haiyan Tu and Yi-Long Wu
    Citation: Journal of Hematology & Oncology 2015 8:54
  27. Male breast cancer is a rare malignancy. Despite the lack of prospectively generated data from trials in either the adjuvant or metastatic setting, patients are commonly treated with hormone therapies. Much co...

    Authors: Luigi Di Lauro, Laura Pizzuti, Maddalena Barba, Domenico Sergi, Isabella Sperduti, Marcella Mottolese, Carla Azzurra Amoreo, Franca Belli, Patrizia Vici, Valerie Speirs, Daniele Santini, Ruggero De Maria and Marcello Maugeri-Saccà
    Citation: Journal of Hematology & Oncology 2015 8:53
  28. The benefit of preoperative chemotherapy in resectable gastroesophageal adenocarcinomas was not observed in signet ring cell subtype. However, the potential interest of taxane-based preoperative chemotherapy o...

    Authors: Stefano Kim, Frederic Fiteni, Sophie Paget-Bailly, François Ghiringhelli, Zaher Lakkis, Marine Jary, Francine Fein, Franck Bonnetain, Christophe Mariette and Christophe Borg
    Citation: Journal of Hematology & Oncology 2015 8:52
  29. Prostate cancer and chronic lymphocytic leukemia (CLL) are relatively common malignancies associated with advanced age. Although immunotherapy-based strategies are used to treat both, currently, there is no ov...

    Authors: Heather H. Cheng, Colleen Soleau and Evan Y. Yu
    Citation: Journal of Hematology & Oncology 2015 8:51
  30. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death, especially in China. And the mechanism of its progression remains poorly understood. Growing evidence indicates that long no...

    Authors: Ming-de Huang, Wen-ming Chen, Fu-zhen Qi, Rui Xia, Ming Sun, Tong-peng Xu, Li Yin, Er-bao Zhang, Wei De and Yong-qian Shu
    Citation: Journal of Hematology & Oncology 2015 8:50

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:143

  31. The Glasgow Prognostic Score (GPS) measures inflammation and proves its prognostic value in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL) which is commonly combined with inflammatory les...

    Authors: Seok Jin Kim, Kyung Ju Ryu, Mineui Hong, Young Hyeh Ko and Won Seog Kim
    Citation: Journal of Hematology & Oncology 2015 8:49

    The Erratum to this article has been published in Journal of Hematology & Oncology 2015 8:112

  32. Minimal residual disease detection in the bone marrow is usually performed in patients with acute myeloid leukemia undergoing one course of induction chemotherapy. To optimize the chemotherapy strategies, more...

    Authors: Cong Yu, Qing-lei Kong, Yun-xiang Zhang, Xiang-qin Weng, Jing Wu, Yan Sheng, Chun-lei Jiang, Yong-mei Zhu, Qi Cao, Shu-min Xiong, Jun-min Li, Xiao-dong Xi, Sai-juan Chen and Bing Chen
    Citation: Journal of Hematology & Oncology 2015 8:48
  33. Eukaryotic cell membrane dynamics change in curvature during physiological and pathological processes. In the past ten years, a novel protein family, Fes/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain protei...

    Authors: Suxuan Liu, Xinyu Xiong, Xianxian Zhao, Xiaofeng Yang and Hong Wang
    Citation: Journal of Hematology & Oncology 2015 8:47
  34. The therapeutic efficacy of arsenic trioxide (As2O3) in acute myeloid leukemia (AML) is modest, which is partly related to its limited intracellular uptake into the leukemic cells. As2O3 enters cells via the tran...

    Authors: David Chau, Karen Ng, Thomas Sau-Yan Chan, Yuen-Yee Cheng, Bonnie Fong, Sidney Tam, Yok-Lam Kwong and Eric Tse
    Citation: Journal of Hematology & Oncology 2015 8:46
  35. TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN) than their de novo counterparts; however, the pattern of mutations involving TP53 gene in t-MN versus de novo disease...

    Authors: Chi Young Ok, Keyur P Patel, Guillermo Garcia-Manero, Mark J Routbort, Jie Peng, Guilin Tang, Maitrayee Goswami, Ken H Young, Rajesh Singh, L Jeffrey Medeiros, Hagop M Kantarjian, Rajyalakshmi Luthra and Sa A Wang
    Citation: Journal of Hematology & Oncology 2015 8:45
  36. Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are approved for patients with recurrent non-small cell lung cancer (NSCLC). However, the efficacy of EGFR-TKIs in NSCLC therapy is limit...

    Authors: Siyuan Dong, Xiaohan Qu, Wenya Li, Xinwen Zhong, Peiwen Li, Shize Yang, Xitao Chen, Mingrui Shao and Lin Zhang
    Citation: Journal of Hematology & Oncology 2015 8:43
  37. Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a...

    Authors: Kristina Karrman, Anders Castor, Mikael Behrendtz, Erik Forestier, Linda Olsson, Mats Ehinger, Andrea Biloglav, Thoas Fioretos, Kajsa Paulsson and Bertil Johansson
    Citation: Journal of Hematology & Oncology 2015 8:42
  38. p53 plays important roles in regulating the metabolic reprogramming of cancer, such as aerobic glycolysis. Oroxylin A is a natural active flavonoid with strong anticancer effects both in vitro and in vivo.

    Authors: Kai Zhao, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Na Lu and Libin Wei
    Citation: Journal of Hematology & Oncology 2015 8:41

    The Correction to this article has been published in Journal of Hematology & Oncology 2019 12:143

  39. Deregulated expression of heat shock proteins (HSPs) encoding genes is frequent in multiple myeloma. HSPs, which are molecular chaperones involved in protein homeostasis pathways, have emerged recently as prom...

    Authors: Sophie Bustany, Julie Cahu, Géraldine Descamps, Catherine Pellat-Deceunynck and Brigitte Sola
    Citation: Journal of Hematology & Oncology 2015 8:40
  40. Novel-targeted therapies are in rapid development for the treatment of acute lymphoblastic leukemia (ALL) to overcome resistance and decrease toxicity. Survivin, a member of the inhibitor of apoptosis gene fam...

    Authors: Bill H Chang, Kara Johnson, Dorian LaTocha, Joelle S J Rowley, Jade Bryant, Russell Burke, Rebecca L Smith, Marc Loriaux, Markus Müschen, Charles Mullighan, Brian J Druker and Jeffrey W Tyner
    Citation: Journal of Hematology & Oncology 2015 8:39
  41. PIWI-interacting RNAs (piRNAs) are a large family of small, single-stranded, non-coding RNAs present throughout the animal kingdom. They form complexes with several members of the PIWI clade of Argonaute prote...

    Authors: Miguel Moyano and Giovanni Stefani
    Citation: Journal of Hematology & Oncology 2015 8:38
  42. Thrombocytopenia is a significant problem in patients with relapsed or refractory multiple myeloma, precipitating a need for supportive platelet transfusions and necessitating decreases in delivered doses of c...

    Authors: Jee-Yeong Jeong, Michelle S Levine, Nirmalee Abayasekara, Nancy Berliner, Jacob Laubach and Gary J Vanasse
    Citation: Journal of Hematology & Oncology 2015 8:37
  43. NK cells expressing TIM-3 show a marked increase in IFNγ production in response to acute myeloid leukemia (AML) blast cells that endogenously express Gal-9. Herein, we demonstrate that NK cell-mediated product...

    Authors: Valentina Folgiero, Loredana Cifaldi, Giuseppina Li Pira, Bianca Maria Goffredo, Luciana Vinti and Franco Locatelli
    Citation: Journal of Hematology & Oncology 2015 8:36
  44. Mantle cell lymphoma (MCL) is a distinct clinical pathologic subtype of B cell non-Hodgkin’s lymphoma often associated with poor prognosis. New therapeutic approaches based on boosting anti-tumor immunity are ...

    Authors: Jingtao Chen, Gerard Zurawski, Sandy Zurawski, Zhiqing Wang, Keiko Akagawa, Sangkon Oh, Ueno Hideki, Joseph Fay, Jacques Banchereau, Wenru Song and A Karolina Palucka
    Citation: Journal of Hematology & Oncology 2015 8:35
  45. We reported that knockdown of PPP2R5C by siRNA led to proliferation inhibition and apoptosis induction in K562 cells. In this study, we further characterized the gene expression profiles after PPP2R5C suppression...

    Authors: Sichu Liu, Qi Shen, Yu Chen, Chengwu Zeng, Changshu Cao, Lijian Yang, Shaohua Chen, Xiuli Wu, Bo Li and Yangqiu Li
    Citation: Journal of Hematology & Oncology 2015 8:34
  46. As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between...

    Authors: Ya-Feng Li, Li-Na Ren, Geng Guo, Lee Anne Cannella, Valeria Chernaya, Sonia Samuel, Su-Xuan Liu, Hong Wang and Xiao-Feng Yang
    Citation: Journal of Hematology & Oncology 2015 8:33
  47. Progression of chronic myelogenous leukemia (CML) is frequently accompanied by cytogenetic evolution, commonly unbalanced chromosomal changes, such as an extra copy of Philadelphia chromosome (Ph), +8, and i(1...

    Authors: Wei Wang, Guilin Tang, Jorge E Cortes, Hui Liu, Di Ai, C Cameron Yin, Shaoying Li, Joseph D Khoury, Carlos Bueso-Ramos, L Jeffrey Medeiros and Shimin Hu
    Citation: Journal of Hematology & Oncology 2015 8:32
  48. Zebrafish is an established model for the study of vertebrate development, and is especially amenable for investigating hematopoiesis, where there is strong conservation of key lineages, genes, and development...

    Authors: Parisa Rasighaemi, Faiza Basheer, Clifford Liongue and Alister C Ward
    Citation: Journal of Hematology & Oncology 2015 8:29

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