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  1. Progression of chronic myelogenous leukemia (CML) is frequently accompanied by cytogenetic evolution, commonly unbalanced chromosomal changes, such as an extra copy of Philadelphia chromosome (Ph), +8, and i(1...

    Authors: Wei Wang, Guilin Tang, Jorge E Cortes, Hui Liu, Di Ai, C Cameron Yin, Shaoying Li, Joseph D Khoury, Carlos Bueso-Ramos, L Jeffrey Medeiros and Shimin Hu
    Citation: Journal of Hematology & Oncology 2015 8:32
    Content type: Research Published on:

  4. Zebrafish is an established model for the study of vertebrate development, and is especially amenable for investigating hematopoiesis, where there is strong conservation of key lineages, genes, and development...

    Authors: Parisa Rasighaemi, Faiza Basheer, Clifford Liongue and Alister C Ward
    Citation: Journal of Hematology & Oncology 2015 8:29
    Content type: Review Published on:

  5. The transcription factor Ecotropic Virus Integration site 1 (EVI1) regulates cellular proliferation, differentiation, and apoptosis, and its overexpression contributes to an aggressive course of disease in mye...

    Authors: Gerwin Heller, Anna Rommer, Katarina Steinleitner, Julia Etzler, Hubert Hackl, Petra Heffeter, Erwin Tomasich, Martin Filipits, Birgit Steinmetz, Thais Topakian, Simone Klingenbrunner, Barbara Ziegler, Andreas Spittler, Sabine Zöchbauer-Müller, Walter Berger and Rotraud Wieser
    Citation: Journal of Hematology & Oncology 2015 8:28
    Content type: Research Published on:

  6. Journal of Hematology & Oncology is pleased to see the exponential growth in the number of publications from China, especially in hematology and oncology. This editorial calls for putting more we...

    Authors: Delong Liu, Weijing Sun, Jingzhou Hou, Ruirong Yuan and Zihai Li
    Citation: Journal of Hematology & Oncology 2015 8:27
    Content type: Editorial Published on:

  7. Aloperine, a natural alkaloid constituent isolated from the herb Sophora alopecuroides displays anti-inflammatory properties in vitro and in vivo. Our group previously demonstrated that aloperine significantly in...

    Authors: He Wang, Shu Yang, Hong Zhou, Mingna Sun, Lingran Du, Minyan Wei, Meixia Luo, Jingzhu Huang, Hongzhu Deng, Yinghong Feng, Jun Huang and Yi Zhou
    Citation: Journal of Hematology & Oncology 2015 8:26
    Content type: Research Published on:

  8. Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. Herein, we report a potential leukocyte differe...

    Authors: Min Xie, Ting Li, Ning Li, Jinlan Li, Qiumei Yao, Wenling Han and Guorui Ruan
    Citation: Journal of Hematology & Oncology 2015 8:25
    Content type: Letter to the Editor Published on:

  9. Trogocytosis is the transfer of plasma membrane fragments and the molecules they contain between one donor and one acceptor/acquirer cell. Through trogocytosis, acceptor cells temporarily display and use cell-...

    Authors: Joel LeMaoult, Julien Caumartin, Marina Daouya, Magdalena Switala, Vera Rebmann, Bertrand Arnulf and Edgardo D Carosella
    Citation: Journal of Hematology & Oncology 2015 8:24
    Content type: Research Published on:

  10. Oct4 and Nanog are key regulatory genes that maintain the pluripotency and self-renewal properties of embryonic stem cells. We previously reported that the two stemness markers were tightly associated with can...

    Authors: Xin Yin, Bo-Heng Zhang, Su-Su Zheng, Dong-Mei Gao, Shuang-Jian Qiu, Wei-Zhong Wu and Zheng-Gang Ren
    Citation: Journal of Hematology & Oncology 2015 8:23
    Content type: Research Published on:

  11. During tumor formation and expansion, increasing glucose metabolism is necessary for unrestricted growth of tumor cells. Expression of key glycolytic enzyme alpha-enolase (ENO1) is controversial and its modula...

    Authors: Qiao-Fen Fu, Yan Liu, Yue Fan, Sheng-Ni Hua, Hong-Ying Qu, Su-Wei Dong, Rui-Lei Li, Meng-Yang Zhao, Yan Zhen, Xiao-Li Yu, Yi-Yu Chen, Rong-Cheng Luo, Rong Li, Li-Bo Li, Xiao-Jie Deng, Wei-Yi Fang…
    Citation: Journal of Hematology & Oncology 2015 8:22
    Content type: Research Published on:

  12. Conventional chemotherapy and radiotherapy for the treatment of lymphoma have notable drawbacks, and passive immunotherapy using a monoclonal antibody is restricted to CD20-positive B cell lymphoma. Therefore,...

    Authors: Jiang Zhu, Shiping He, Jie Du, Zhulin Wang, Wang Li, Xianxiong Chen, Wenqi Jiang, Duo Zheng and Guangyi Jin
    Citation: Journal of Hematology & Oncology 2015 8:21
    Content type: Research Published on:

  13. RIP140 is a transcriptional coregulator, (also known as NRIP1), which finely tunes the activity of various transcription factors and plays very important physiological roles. Noticeably, the RIP140 gene has be...

    Authors: Marion Lapierre, Audrey Castet-Nicolas, Delphine Gitenay, Stéphan Jalaguier, Catherine Teyssier, Caroline Bret, Guillaume Cartron, Jérôme Moreaux and Vincent Cavaillès
    Citation: Journal of Hematology & Oncology 2015 8:20
    Content type: Review Published on:

  15. Leukemic stem cells (LSCs) are frequently seen as a cause of treatment failure and relapse in patients with acute myeloid leukemia (AML). Thus, successful new therapeutic strategies for the treatment of AML sh...

    Authors: Dongmei Fan, Zhenzhen Li, Xiaolong Zhang, Yuqi Yang, Xiangfei Yuan, Xiuli Zhang, Ming Yang, Yizhi Zhang and Dongsheng Xiong
    Citation: Journal of Hematology & Oncology 2015 8:18
    Content type: Research Published on:

  16. Anaplastic lymphoma kinase 1 (ALK-1) is a member of the insulin receptor tyrosine kinase family. ALK-1 was initially found in anaplastic large cell lymphoma (ALCL). ALK mutations have also been implicated in t...

    Authors: Chaitanya Iragavarapu, Milaim Mustafa, Akintunde Akinleye, Muhammad Furqan, Varun Mittal, Shundong Cang and Delong Liu
    Citation: Journal of Hematology & Oncology 2015 8:17
    Content type: Review Published on:

  17. Since their description and identification in leukemias and solid tumors, cancer stem cells (CSC) have been the subject of intensive research in translational oncology. Indeed, recent advances have led to the ...

    Authors: Axel Schulenburg, Katharina Blatt, Sabine Cerny-Reiterer, Irina Sadovnik, Harald Herrmann, Brigitte Marian, Thomas W Grunt, Christoph C Zielinski and Peter Valent
    Citation: Journal of Hematology & Oncology 2015 8:16
    Content type: Review Published on:

  18. DNA methyltransferase 1 (Dnmt1) regulates expression of many critical genes through maintaining parental DNA methylation patterns on daughter DNA strands during mitosis. It is essential for embryonic developme...

    Authors: Xiaohui Liu, Xiaoe Jia, Hao Yuan, Ke Ma, Yi Chen, Yi Jin, Min Deng, Weijun Pan, Saijuan Chen, Zhu Chen, Hugues de The, Leonard I Zon, Yi Zhou, Jun Zhou and Jun Zhu
    Citation: Journal of Hematology & Oncology 2015 8:15
    Content type: Research Published on:

  19. Anticancer treatments aiming at killing malignant cells have been applied for decades but have been unsuccessful at curing the disease. The modern concept of tumor microenvironment, especially angiogenesis, su...

    Authors: Li Zhang, C Alexander Valencia, Biao Dong, Meng Chen, Pu-Jun Guan and Ling Pan
    Citation: Journal of Hematology & Oncology 2015 8:14
    Content type: Review Published on:

  20. Expression of surface NKG2D ligand MIC on tumor cells is deemed to stimulate NK and co-stimulate CD8 T cell anti-tumor immunity. Human cancer cells however frequently adopt a proteinase-mediated shedding strat...

    Authors: Gang Xiao, Xuanjun Wang, Jun Sheng, Shengjun Lu, Xuezhong Yu and Jennifer D Wu
    Citation: Journal of Hematology & Oncology 2015 8:13
    Content type: Research Published on:

  22. Neuroguidin (NGDN) is a eukaryotic translation initiation factor 4E binding protein. The purpose of this study was to clarify the function of NGDN and its possible mechanism of action in human myeloid leukemia...

    Authors: Kejun Chen, Shuqing Lü, Hui Cheng, Gusheng Tang, Min Liu, Hong Zhou and Jianmin Wang
    Citation: Journal of Hematology & Oncology 2015 8:11
    Content type: Letter to the Editor Published on:

  23. Insulin like growth factor binding protein 7 (IGFBP7) is a secreted protein binding insulin like growth factor 1 (IGF-1), insulin, vascular endothelial growth factor A (VEGFA), and activin A. It antagonizes bo...

    Authors: Arnold Bolomsky, Dirk Hose, Martin Schreder, Anja Seckinger, Susanne Lipp, Bernard Klein, Daniel Heintel, Heinz Ludwig and Niklas Zojer
    Citation: Journal of Hematology & Oncology 2015 8:10
    Content type: Research Published on:

  24. Notch1 transmembrane receptor is activated through ligand-binding- triggered proteolytic cleavages and, upon release, the intracellular domain (N1-ICD) translocates into the nucleus and modulates target gene t...

    Authors: Dat Nguyen, Larry Rubinstein, Naoko Takebe, Lucio Miele, Joseph E Tomaszewski, Percy Ivy, James H Doroshow and Sherry X Yang
    Citation: Journal of Hematology & Oncology 2015 8:9
    Content type: Research Published on:

  25. Hematologic disease affects people of all ages worldwide. In the past decade, researchers have made great progress in the field of hematology. In the present study we compared the hematology research output fr...

    Authors: Lei Zhang, Xin Ye, Yi Sun, An-mei Deng and Bao-hua Qian
    Citation: Journal of Hematology & Oncology 2015 8:8
    Content type: Research Published on:

  26. Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in v...

    Authors: Yiren Xiao, Xinru Wei, Zhiwu Jiang, Xiangmeng Wang, Wei Ye, Xin Liu, Minjie Zhang, Yan Xu, Donghai Wu, Liangxue Lai, Huihui Yao, Zixia Liu, Su Cao, Pentao Liu, Bing Xu, Yangqiu Li…
    Citation: Journal of Hematology & Oncology 2015 8:7
    Content type: Letter to the Editor Published on:

  28. The prognosis of relapsed acute myeloid leukemia (AML) in elderly patients is dismal, even if the AML exhibits a good prognostic karyotype, such as inv(16)(p13.1q22). We present a 72-year-old female with AML w...

    Authors: Masahisa Arahata, Yukihiro Shimizu, Hidesaku Asakura and Shinji Nakao
    Citation: Journal of Hematology & Oncology 2015 8:5
    Content type: Letter to the Editor Published on:

  29. Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT).

    Authors: Frédéric Baron, Pierre Zachée, Johan Maertens, Tessa Kerre, Aurélie Ory, Laurence Seidel, Carlos Graux, Philippe Lewalle, Michel Van Gelder, Koen Theunissen, Evelyne Willems, Marie-Paule Emonds, Ann De Becker and Yves Beguin
    Citation: Journal of Hematology & Oncology 2015 8:4
    Content type: Research Published on:

  30. The tyrosine kinase receptor insulin-like growth factor 1 receptor (IGF-IR) contributes to the initiation and progression of many types of malignancies. We previously showed that IGF-2, which binds IGF-IR, is ...

    Authors: Jingjing Xie, Xiaoli Chen, Junke Zheng, Chunling Li, Satomi Stacy, Martin Holzenberger, Xuemei Hu and Cheng Cheng Zhang
    Citation: Journal of Hematology & Oncology 2015 8:3
    Content type: Research Published on:

  31. High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target who...

    Authors: Xiaoyun Han, Xiugui Sheng, Hannah M Jones, Amanda L Jackson, Joshua Kilgore, Jessica E Stine, Monica N Schointuch, Chunxiao Zhou and Victoria L Bae-Jump
    Citation: Journal of Hematology & Oncology 2015 8:2
    Content type: Letter to the Editor Published on:

  32. Acute leukemia is currently the major cause of death in hematological malignancies. Despite the rapid development of new therapies, minimal residual disease (MRD) continues to occur and leads to poor outcomes....

    Authors: Kaimin Hu, Yanjun Gu, Lixia Lou, Lizhen Liu, Yongxian Hu, Binsheng Wang, Yi Luo, Jimin Shi, Xiaohong Yu and He Huang
    Citation: Journal of Hematology & Oncology 2015 8:1
    Content type: Research Published on:

  33. Although, substantial experimental evidence related to diagnosis and treatment of pediatric central nervous system (CNS) neoplasms have been demonstrated, the understanding of the etiology and pathogenesis of ...

    Authors: Maria Braoudaki, George I Lambrou, Krinio Giannikou, Vasilis Milionis, Kalliopi Stefanaki, Diane K Birks, Neophytos Prodromou, Aggeliki Kolialexi, Antonis Kattamis, Chara A Spiliopoulou, Fotini Tzortzatou-Stathopoulou and Emmanouel Kanavakis
    Citation: Journal of Hematology & Oncology 2014 7:96
    Content type: Research Published on:

  34. Although distinct patterns of homeobox (HOX) gene expression have been described in defined cytogenetic and molecular subsets of patients with acute myeloid leukemia (AML), it is unknown whether these patterns ar...

    Authors: Karolina Skvarova Kramarzova, Karel Fiser, Ester Mejstrikova, Katerina Rejlova, Marketa Zaliova, Maarten Fornerod, Harry A Drabkin, Marry M van den Heuvel-Eibrink, Jan Stary, Jan Trka and Julia Starkova
    Citation: Journal of Hematology & Oncology 2014 7:94
    Content type: Research Published on:

  35. Most patients with small cell lung cancer (SCLC) or neuroblastoma (NB) already show clinically detectable metastases at diagnosis and have an extremely poor prognosis even when treated with combined modalities...

    Authors: Debra Ehrlich, Bo Wang, Wei Lu, Peter Dowling and Ruirong Yuan
    Citation: Journal of Hematology & Oncology 2014 7:91
    Content type: Research Published on:

  36. We characterized bone marrow stromal cells (BMSC) from patients with pre-fibrotic myeloproliferative neoplasms (MPN). MPN-BMSC showed decreased capacity to stimulate the proliferation of colony-forming units o...

    Authors: Rebekka K Schneider, Susanne Ziegler, Isabelle Leisten, Monica SV Ferreira, Anne Schumacher, Björn Rath, Dirk Fahrenkamp, Gerhard Müller-Newen, Martina Crysandt, Stefan Wilop, Edgar Jost, Steffen Koschmieder, Ruth Knüchel, Tim H Brümmendorf and Patrick Ziegler
    Citation: Journal of Hematology & Oncology 2014 7:92
    Content type: Letter to the Editor Published on:

  37. According to the 2008 World Health Organization classification, chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia are rare diseases. The remarkable progress i...

    Authors: Bing Li, Robert Peter Gale and Zhijian Xiao
    Citation: Journal of Hematology & Oncology 2014 7:93
    Content type: Review Published on:

  39. Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. The expr...

    Authors: Gregory Loewen, Janarthanan Jayawickramarajah, Ying Zhuo and Bin Shan
    Citation: Journal of Hematology & Oncology 2014 7:90
    Content type: Review Published on:

  40. The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS) highlights the importance of the RNA-splicing machinery in MDS....

    Authors: Valeria Visconte, Ali Tabarroki, Li Zhang, Yvonne Parker, Edy Hasrouni, Reda Mahfouz, Kyoichi Isono, Haruhiko Koseki, Mikkael A Sekeres, Yogen Saunthararajah, John Barnard, Daniel Lindner, Heesun J Rogers and Ramon V Tiu
    Citation: Journal of Hematology & Oncology 2014 7:89
    Content type: Research Published on:

  41. Peripheral T-cell lymphomas (PTCLs) are often aggressive tumors and resistant to conventional chemotherapy. Dysregulation of extrinsic apoptosis plays an important role on tumor cell sensitivity to chemotherap...

    Authors: Zhong Zheng, Shu Cheng, Wen Wu, Li Wang, Yan Zhao, Yang Shen, Anne Janin and Wei-Li Zhao
    Citation: Journal of Hematology & Oncology 2014 7:88
    Content type: Research Published on:

  42. Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell ...

    Authors: Xun Yuan, Hua Wu, Na Han, Hanxiao Xu, Qian Chu, Shiying Yu, Yuan Chen and Kongming Wu
    Citation: Journal of Hematology & Oncology 2014 7:87
    Content type: Review Published on:

  43. Since the discovery of circulating microRNAs (miRNAs) in body fluids, an increasing number of studies have focused on their potential as non-invasive biomarkers and as therapeutic targets or tools for many dis...

    Authors: Wen-Tao Wang and Yue-Qin Chen
    Citation: Journal of Hematology & Oncology 2014 7:86
    Content type: Review Published on:

  44. Shuttling of specific proteins out of the nucleus is essential for the regulation of the cell cycle and proliferation of both normal and malignant tissues. Dysregulation of this fundamental process may affect ...

    Authors: Giovanni Luca Gravina, William Senapedis, Dilara McCauley, Erkan Baloglu, Sharon Shacham and Claudio Festuccia
    Citation: Journal of Hematology & Oncology 2014 7:85
    Content type: Review Published on:

  45. While microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies ...

    Authors: Minlee Kim and Frank J Slack
    Citation: Journal of Hematology & Oncology 2014 7:84
    Content type: Research highlight Published on:

  47. Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.

    Authors: Santiago Schiaffino-Ortega, Carlos Balinas, Marta Cuadros and Pedro P Medina
    Citation: Journal of Hematology & Oncology 2014 7:81
    Content type: Research highlight Published on:

  48. Here, we report and investigate the genomic alterations of two novel cases of Non-Hodgkin Lymphoma (NHL) in children with Williams-Beuren syndrome (WBS), a multisystem disorder caused by 7q11.23 hemizygous del...

    Authors: David Guenat, Samuel Quentin, Carmelo Rizzari, Catarina Lundin, Tiziana Coliva, Patrick Edery, Helen Fryssira, Laurent Bermont, Christophe Ferrand, Jean Soulier, Christophe Borg and Pierre-Simon Rohrlich
    Citation: Journal of Hematology & Oncology 2014 7:82
    Content type: Letter to the Editor Published on:

  49. Leukemia is a systemic malignancy originated from hematopoietic cells. The extracellular environment has great impacts on the survival, proliferation and dissemination of leukemia cells. The spleen is an impor...

    Authors: Shihui Ma, Yingxu Shi, Yakun Pang, Fang Dong, Hui Cheng, Sha Hao, Jing Xu, Xiaofan Zhu, Weiping Yuan, Tao Cheng and Guoguang Zheng
    Citation: Journal of Hematology & Oncology 2014 7:71
    Content type: Research Published on:

  50. Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is...

    Authors: Ying Shao, Zhongjian Cheng, Xinyuan Li, Valeria Chernaya, Hong Wang and Xiao-feng Yang
    Citation: Journal of Hematology & Oncology 2014 7:80
    Content type: Review Published on:
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Journal of Hematology & Oncology

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