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  1. Review

    Extracellular vesicles-mediated noncoding RNAs transfer in cancer

    Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including microRN...

    Pei Ma, Yutian Pan, Wei Li, Chongqi Sun, Jie Liu, Tongpeng Xu and Yongqian Shu

    Journal of Hematology & Oncology 2017 10:57

    Published on: 23 February 2017

  2. Research

    Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor d-1-methyl-tryptophan

    Although blinatumomab, a bispecific T cell engaging antibody, exhibits high clinical response rates in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgk...

    Xiaolong Zhang, Yuanyuan Yang, Leisheng Zhang, Yang Lu, Qing Zhang, Dongmei Fan, Yizhi Zhang, Yanjun Zhang, Zhou Ye and Dongsheng Xiong

    Journal of Hematology & Oncology 2017 10:56

    Published on: 23 February 2017

  3. Research

    Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera

    The driver mutations JAK2V617F, MPLW515L/K and CALR influence disease phenotype of myeloproliferative neoplasms (MPNs) and might sustain a condition of chronic inflammation. Pentraxin 3 (PTX3) and high-sensitivit...

    Federico Lussana, Alessandra Carobbio, Silvia Salmoiraghi, Paola Guglielmelli, Alessandro Maria Vannucchi, Barbara Bottazzi, Roberto Leone, Alberto Mantovani, Tiziano Barbui and Alessandro Rambaldi

    Journal of Hematology & Oncology 2017 10:54

    Published on: 22 February 2017

  4. Research

    Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial

    The randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial evaluated the JAK1/JAK2 inhibitor ruxolitinib in patients with intermediate-2/high-risk myelofibrosis. The primary and planned 3-year a...

    Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W. N. Deininger, Carole B. Miller, Richard T. Silver, Moshe Talpaz, Elliott F. Winton, Jimmie H. Harvey, Murat O. Arcasoy, Elizabeth O. Hexner, Roger M. Lyons, Ronald Paquette…

    Journal of Hematology & Oncology 2017 10:55

    Published on: 22 February 2017

  5. Review

    New development in CAR-T cell therapy

    Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-...

    Zhenguang Wang, Zhiqiang Wu, Yang Liu and Weidong Han

    Journal of Hematology & Oncology 2017 10:53

    Published on: 21 February 2017

  6. Review

    Paxillin: a crossroad in pathological cell migration

    Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell mov...

    Ana María López-Colomé, Irene Lee-Rivera, Regina Benavides-Hidalgo and Edith López

    Journal of Hematology & Oncology 2017 10:50

    Published on: 18 February 2017

  7. Research

    Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancer

    Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and cancer progression. Recently, the lncRNA AGAP2-AS1 was identified as an oncogenic lncRNA in human non-small cell lung can...

    Fuzhen Qi, Xianghua Liu, Hao Wu, Xiang Yu, Chenchen Wei, Xiaodan Huang, Guozhong Ji, Fengqi Nie and Keming Wang

    Journal of Hematology & Oncology 2017 10:48

    Published on: 16 February 2017

  8. Letter to the Editor

    Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia

    Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many patients, effective therapy is ...

    Lili Tao, Qingshu Zeng, June Li, Miao Xu, Jiajia Wang, Ying Pan, Huiping Wang, Qianshan Tao, Yang Chen, Jun Peng, Ming Hou, Arend Jan Gerard Jansen, Heyu Ni and Zhimin Zhai

    Journal of Hematology & Oncology 2017 10:46

    Published on: 8 February 2017

  9. Letter to the Editor

    Clinical impact of extensive molecular profiling in advanced cancer patients

    Previous precision medicine studies have investigated conventional molecular techniques and/or limited sets of gene alterations. The aim of this study was to describe the impact of the next-generation sequenci...

    Sophie Cousin, Thomas Grellety, Maud Toulmonde, Céline Auzanneau, Emmanuel Khalifa, Yec’han Laizet, Kevin Tran, Sylvestre Le Moulec, Anne Floquet, Delphine Garbay, Jacques Robert, Isabelle Hostein, Isabelle Soubeyran and Antoine Italiano

    Journal of Hematology & Oncology 2017 10:45

    Published on: 8 February 2017

  10. Letter to the Editor

    A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13

    We developed a novel murine monoclonal antibody (mAb) against the C-terminal α-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and A...

    Lulu Zhang, Jian Su, Fei Shen, Zhenni Ma, Yiming Zhao, Lijun Xia and Changgeng Ruan

    Journal of Hematology & Oncology 2017 10:42

    Published on: 6 February 2017

  11. Research

    The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia

    The optimal monitoring schedules and cutoff minimal residual disease (MRD) levels for the accurate prediction of relapse at all time points after allogeneic hematopoietic stem cell transplantation (allo-HSCT) ...

    Ya-Zhen Qin, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Wei Han, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yao Chen, Xiao-Dong Mo, Xiao-Su Zhao, Ying-Jun Chang, Kai-Yan Liu and Xiao-Jun Huang

    Journal of Hematology & Oncology 2017 10:44

    Published on: 6 February 2017

  12. Research

    Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer

    Numerous DNA-damaging cellular stresses, including oncogene activation and DNA-damage response (DDR), may lead to cellular senescence. Previous observations linked microRNA deregulation with altered senescent ...

    João Ramalho-Carvalho, Inês Graça, Antonio Gomez, Jorge Oliveira, Rui Henrique, Manel Esteller and Carmen Jerónimo

    Journal of Hematology & Oncology 2017 10:43

    Published on: 6 February 2017

  13. Letter to the Editor

    Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia

    Methylation of N6 adenosine (m6A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing. However, its role in the d...

    Chau-To Kwok, Amy D. Marshall, John E. J. Rasko and Justin J. L. Wong

    Journal of Hematology & Oncology 2017 10:39

    Published on: 2 February 2017

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:49

  14. Research

    Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

    It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues i...

    Ya-feng Li, Gayani Nanayakkara, Yu Sun, Xinyuan Li, Luqiao Wang, Ramon Cueto, Ying Shao, Hangfei Fu, Candice Johnson, Jiali Cheng, Xiongwen Chen, Wenhui Hu, Jun Yu, Eric T. Choi, Hong Wang and Xiao-feng Yang

    Journal of Hematology & Oncology 2017 10:40

    Published on: 2 February 2017

  15. Review

    Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia

    Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methyl...

    Yan Li, Qingyu Xu, Na Lv, Lili Wang, Hongmei Zhao, Xiuli Wang, Jing Guo, Chongjian Chen, Yonghui Li and Li Yu

    Journal of Hematology & Oncology 2017 10:41

    Published on: 2 February 2017

  16. Research

    Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

    Klotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast growth factor (FGF), and Wnt signaling pathways. T...

    Xiangxiang Zhou, Xiaosheng Fang, Yujie Jiang, Lingyun Geng, Xinyu Li, Ying Li, Kang Lu, Peipei Li, Xiao Lv and Xin Wang

    Journal of Hematology & Oncology 2017 10:37

    Published on: 2 February 2017

  17. Letter to the Editor

    MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

    The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that ...

    Pei Li, Yang Yang, Hui Liu, An-Kui Yang, Jin-Ming Di, Guang-Mou Tan, Hai-Feng Wang, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Di-Wei Zheng, Yao Chen, Meng-Ning Wei, Jia-Rong Huang, Kun Wang, Zhi Shi…

    Journal of Hematology & Oncology 2017 10:32

    Published on: 25 January 2017

  18. Research

    Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

    Thrombospondin-2 (TSP-2) is a secreted matricellular glycoprotein that is found to mediate cell-to-extracellular matrix attachment and participates in many physiological and pathological processes. The express...

    Po-Chun Chen, Chih-Hsin Tang, Liang-Wei Lin, Chun-Hao Tsai, Cheng-Ying Chu, Tien-Huang Lin and Yuan-Li Huang

    Journal of Hematology & Oncology 2017 10:33

    Published on: 25 January 2017

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