Figure 2

Engraftment and growth patterns of leukemia blasts derived from individual patients with different clinical status in SCID mice. a. Leukemia blasts obtained from MA11 at initial diagnosis did not engraft and growth in SCID mice. The cells collected from her first relapse (rel-1) and second relapse (rel-2) was grown in the mice in an indolent manner, respectively. The patient died of leukemia 2 months later after the injection of rel-2 cells. b. BA35 was a patient with pre-B-ALL. Leukemia sample from initial diagnosis was not studied. The blasts of rel-1 were not able to engraft and grow. Cells from rel-2 and rel-3/ref displayed an indolent and aggressive growth pattern, respectively. The patient died of leukemia 3 months after refractory disease development. c. TA7 was from a newly diagnosed patient with T-ALL. Leukemia cells from initial diagnosis did not grow. Cells from first relapse had an aggressive growth pattern. Leukemic cells recovered from subcutaneous tumor, were able to initiate a more rapid proliferation than the cells in first passage. d. BA17 was a pre-B-ALL who relapsed after a 40 months complete remission and died of leukemia progression 3 months after relapse. His leukemia cells from rel-1 displayed an indolent growth. However, the adoptive growth in second and third passages displayed an aggressive growth pattern.