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Table 3 Response and PFS by RRM1 SNPs

From: RRM1 single nucleotide polymorphism -37C→A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy

RRM1 SNPs

Response1 (n)

P value2

PFS(weeks)

P value3

 

PR

SD

PD

   

A(-)37A

1

7

2

 

24.7

 

C(-)37C

2

20

2

 

23.3

 

A(-)37C

6

14

2

0.514

30.7

0.043

A2455A

5

22

2

 

26.9

 

G2455G

2

6

3

 

22.0

 

A2455G

2

13

1

0.849

30.7

0.327

G2464G

0

7

1

 

23.9

 

A2464A

6

20

5

 

24.7

 

G2464A

3

13

1

0.191

27.4

0.973

  1. 1 Genomic DNA from 56 patients was available for the analysis of RRM1 SNPs and response.
  2. 2 Kendall's tau correlation
  3. 3 Kaplan-Meier survival estimates.
  4. Abbreviations: PR, Partial response; SD, Stable disease; PD, Progressive disease; PFS, Progression-free survival.
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Journal of Hematology & Oncology

ISSN: 1756-8722

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