Staged Approach N = 25 | PAD N = 31 | VTD N = 35 | p-value | |
---|---|---|---|---|
(A) Demographics | ||||
Mean age | 52.44 | 53.42 | 55.71 | 0.18 |
Male gender | 17 (68 %) | 15 (48.4 %) | 18 (51.4 %) | 0.296 |
Isotype | 0.504 | |||
G | 12 | 15 | 13 | |
L | 6 | 8 | 11 | |
A | 4 | 2 | 9 | |
D | 2 | 4 | 1 | |
NS | 1 | 2 | 1 | |
ISS | 0.83 | |||
I | 7 (28 %) | 11 (35.5 %) | 11 (32.4 %) | |
II | 7 (28 %) | 5 (16.1 %) | 6 (17.6 %) | |
III | 11 (44 %) | 14 (48.4 %) | 17 (50 %) | |
High-risk Karyotype | 3/5 (60 %) | 2/6 (33.3 %) | 4/12 (25 %) | 0.35 |
(B) Outcomes | ||||
CR/nCR post-induction | 6 (24 %) | 13 (41.9 %) | 15 (42.9 %) | 0.268 |
≥VGPR post-induction | 14 (56 %) | 26 (83.9 %) | 26 (74.3 %) | 0.064 |
CR/nCR post-ASCT | 15 (62.5 %) | 23 (74.2 %) | 19 (63.3 %) | 0.569 |
≥VGPR post-ASCT | 19 (79.2 %) | 29 (93.5 %) | 27 (90 %) | 0.242 |
5-year OS | 59.80 % | 78.70 % | 73.80 % | 0.661 |
5-year EFS | 36.30 % | 52.50 % | 69.80 % | 0.516 |