Figure 4From: Abnormal hematopoietic phenotypes in Pim kinase triple knockout miceDelayed hematological recovery and reduced donor cell contribution in secondary transplant mice receiving BM cells from Pim TKO primary transplant recipients. BM cells were harvested from primary transplant recipients at 4 months post transplantation and injected into lethally irradiated female FVB recipients (1 × 107/mouse). (A) Lower peripheral white blood cell counts in Pim TKO secondary transplant recipient mice. Peripheral white blood cell count in the secondary transplant recipient mice was measured at 3 months post transplant (n=6 for WT; n=3 for Pim TKO mice, *p < 0.05). (B) Reduced donor cell engraftment in the BM of Pim TKO secondary transplant recipient mice. The secondary transplant recipient mice were sacrificed at 4 months post transplant and BM cells were harvested and analyzed for male donor cell engraftment (*p < 0.05).Back to article page