Inosine Triphosphate Pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defects

Table 1 Characteristics of a cohort of 85 adult hematological malignancy patients participating in this study

Attributes	MDS	CLL	AML
Number	39	28	18
Age (year):	75 (54–90)	68 (37–84)	69 (39–85)
median (range)	75 (54–90)	68 (37–84)	69 (39–85)
Sex: (Male/Female)	22/17	21/7	7/11
Sample type:
Peripheral blood	30	23	17
Bone marrow	9	5	1
Classification (n)	RAEB (n=3), RAEB-1 (n=3),	CLL (n=28)	AMLAMDS (n=9),
	RAEB-2 (n=7), MDP5q (n=1),		AMLDN (n=6),
	RCMD (n=13), MDSU (n=2),		AML16 (n=1),
	RCMD (n=13), MDSU (n=2),		AML/TLD (n=2)
	RA (n=1), RARS(n=2),		AML/TLD (n=2)
	CMML (n=6),CMML-1 (n=1)

MDS: Myelodysplastic syndromes; RA: Refractory anaemia; RARS: Refractory anaemia with ringed sideroblasts; RAEB: Refractory anaemia with excess blasts; RCMD: Refractory cytopenia with multilineage dysplasia; MDSU: Myelodysplastic syndrome unclassifiable; MDP5q: Myelodysplastic syndrome associated with isolated (del)5q chromosomal abnormality; CMML: Chronic myelomonocytic leukaemia; AML: Acute myeloid leukaemia; AML/TLD: Acute myeloid leukaemia with trilineage dysplasia; AMLAMDS: Acute myeloid leukaemia with multilineage dysplasia with prior myelodysplasia; AMLDN: Acute myeloid leukaemia with multilineage dysplasia without prior myelodysplasia; AML16: AML with abnormal bone marrow eosinophils (inv)16(p13q22) or t(16;16)(p13;q22); (CBFb/MYH11); CLL: Chronic lymphocytic leukaemia.

ISSN: 1756-8722