Table 5 Comparison of PK parameters between Chinese, Caucasian and Japanese patients

AUC_0-24 (ng.hr/ml)^a

1846 (1361, 2503)

992(801, 1230)

1,470 (914, 2,360)

Cmax (ng/ml)^a

210 (150, 295)

112(84.6, 148)

187 (115, 304)

Tmax (hr)^b

4.03 (2.00, 7.97)

2.79(1.42, 9.78)

4.00 (4.00, 8.00)

t_1/2 (hr)

52.9 (40.2, 65.6)^c

42.0(17.7)^d

55.8 (50.95, 60.65)^c

AUC_0-24 (ng.hr/ml)

2014 (1485, 2731)

1882(1630, 2180)

2,120 (1,320, 3,410)

C_max (ng/ml)

167 (119, 234)

160(136, 188)

188 (116, 306)

T_max (hr)

4.00 (0.00, 6.00)

--

4.04 (4.00, 8.15)

AUC_0-24

1.3(1.0, 1.6)

1.90(1.63, 2.21)

1.44 (1.05, 1.99)

C_max

1.1(0.8, 1.4)

1.43(1.22, 1.68)

1.01 (0.674, 1.50)