Figure 1From: Detection of TP53 dysfunction in chronic lymphocytic leukemia by an in vitro functional assay based on TP53 activation by the non-genotoxic drug Nutlin-3: a proposal for clinical applicationSet up of a western blot assay to detect TP53 dysfunction. A) Figure shows results from western blot assay on the series of the 5 cell lines, in particular EHEB (TP53wt/wt) with a normal pattern, MEC-1 (TP53del/mut), MAVER-1 (TP53del/mut), RAJI (TP53mut/wt) with a mutant pattern, and HL60 (TP53del/del) with a null pattern. B) Figure shows prototypic results from western blot assay of CLL cases with a normal pattern, with an intermediate pattern and with a mutant pattern. C) Histograms show the functional classification according to western blot assay of CLL cases of the training cohort subdivided into the main genetic subgroups. For each functional category the subdivision in genetic subgroup is indicated.Back to article page