Treatment arm | MK-2206 dose, mg | Schedulea | Combination with: |
---|---|---|---|
1 | 45 | QOD | Carboplatin (IV, AUC6, 1-hour infusion) and paclitaxel (IV, 200 mg/m2, 3-hour infusion) |
60 | |||
90 | Q3W | ||
135 | |||
200 | |||
2 | 45 | QOD | Docetaxel (IV, 75 mg/m2, 1-hour infusion) |
90 | Q3W | Docetaxel (IV, 60 mg/m2, 1-hour infusion) | |
135 | |||
200 | |||
3 | 45 | QOD* | Erlotinib (oral, 100 mg, QD) |
45 | Erlotinib (oral, 150 mg, QD) | ||
135 | QW | Erlotinib (oral, 100 mg, QD) | |
135 | Erlotinib (oral, 150 mg, QD) |