Figure 2

Function of TF in cancer progression. flTF forms TF/FVIIa complex and subsequently induce PAR signaling. PKC is phosphorylated by activated PAR complex, which leads to p-PKC translocation. PAR can also induce MAPK and PI3K activation, both of which trigger pro-tumor effects, such as proliferation, angiogenesis and metastasis. Binding to activator protein (AP) can also induce c-Jun upregulation and in turn promote tumor progression. Moreover, flTF binding to ABP-280 leads to actin modulation, resulting in tumor cells metastasis. asTF binds to integrin receptor and enhance the ability of migration, in turn leading to tumor cell angiogenesis and migration.