Figure 8

Effect of GAS5 and gefitinib on the activity of the EGFR/PI3K/AKT pathway and IGF-1R in vivo. (A) Significant suppression of EGFR, downstream signaling molecules, and IGF-1R are seen following co-treatment with GAS5 and gefitinib. (B) Relative levels of P-EGFR, P-AKT, P-ERK, and P-IGF-1R proteins expression in four groups. The data represent the mean ± SD from three independent experiments. *P < 0.05