From: PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective
Contributions | CTLA-4 | PD-1 | PD-L1 (B7-H1) |
---|---|---|---|
Gene Cloning | Pierre Goldstein (1987) [59] | Tasuku Honjo (1992) [57] | Lieping Chen (1999) [47] |
Inhibitory Function | Jeffery Bluestone (1994) [30] Arlene Sharpe (1995) [32] Tak Mak (1995) [33] | Tasuku Honjo (1999) [60] | Lieping Chen (1999) [47] Tasuku Honjo, Clive Wood (2000) [57] b Lieping Chen (2004) [68] |
Ligand-receptor Interaction | Peter Linsley (1991) [25] | Tasuku Honjo, Clive Wood (2000) [57] b | Tasuku Honjo, Clive Wood (2000) [57] b |
Function in cancer immunity | James Allison (1996) [34] | NagahiroMinato (2002) [63] Lieping Chen (2005) [70] Tasuku Honjo (2005) [71] | Lieping Chen (2002) [56] Nagahiro Minato (2002) [63] |