Fig. 1
From: Extracellular vesicles-mediated noncoding RNAs transfer in cancer
EV-associated ncRNAs in cancer. EV-associated ncRNAs contribute to the five types of function in cancer. Selected examples of EV-associated ncRNAs and their mechanisms are shown in cancer initiation, formation of vessels, drug resisitance, metastasis, and immunity. (1) Cancerous cells might discard anti-tumorigenic miRNAs via EVs to stimulate cancer initiation and progression. (2) There exists a positive feedback loop between MM cells and MSC that MM cells promote the increase of miR146a in MSC leading to more cytokine secretion, which in turn favors MM cell growth and migration