From: Extracellular vesicles-mediated noncoding RNAs transfer in cancer
lncRNA | Cancer type | Biological function | Mechanism | Refs |
---|---|---|---|---|
lncRNA-p21 | Prostate cancer | Suppress cancer initiation | Enhance drug resistance; suppress the genes regulated by p53 | [71] |
GAS5 | Prostate cancer | Suppress cancer initiation | Suppress several anti-apoptotic genes | [72] |
MEG3 | Lung cancer | Suppress cancer initiation | Stimulate p53 expression | [73] |
HOTAIR | Bladder cancer | Facilitate tumor progression | Regulate EMT and act as miR-205 sponge | [78] |
MALAT1 | Cervical cancer | Facilitate tumor progression | Modulate EMT | [79] |
MONC | AKML | Facilitate tumor progression | Act as miR-99a/100~125b sponge | [81] |
MIR100HG | AKML | Facilitate tumor progression | Same as lnc-MONC | [81] |
H19 | Liver cancer | Promote angiogenesis | Affect phenotype of endothelial cells | [86] |
linc-ROR | HCC | Promote tumor progression | Inhibit p53 and act as miR-145 sponge | |
linc-ROR | HCC | Enhance drug resistance | Elevate TGF level | [90] |
Linc-VLDLR | HCC | Enhance drug resistance | Unknown | [67] |
lncARSR | Renal cancer | Enhance drug resistance | Act as a ceRNA for miR-34 and miR-449 | [91] |