OS | RFS | |||
---|---|---|---|---|
HR2 | P value | HR2 | P value | |
Univarite analysis (mut/all) | ||||
PTPN11 mut; positive vs negative in full cohort (8/117) | 0.043 | 0.040 | 0.044 | 0.047 |
In B-ALL (7/92) | 0.042 | 0.041 | 0.042 | 0.047 |
In Ph−B-ALL (7/54) | 0.035 | 0.030 | 0.037 | 0.047 |
JAK2 Mut; positive vs negative in full cohort (7/117) | 3.02 | 0.031 | 3.309 | 0.018 |
In B-ALL (5/92) | 3.033 | 0.061 | 3.145 | 0.051 |
In Ph−B-ALL (5/54) | 3.728 | 0.035 | 3.780 | 0.031 |
JAK1 mut; positive vs negative in Ph−B-ALL (4/54) | 6.808 | 0.001 | 6.562 | 0.001 |
NOTCH1 and/or FBXW7 mut; positive vs negative | ||||
In T-ALL (12/25) | 0.204 | 0.035 | 0.223 | 0.048 |
Multivariate analysis | ||||
PTPN11 mut; positive vs negative in full cohort | 0.043 | 0.052 | 0.044 | 0.056 |
In B-ALL | 0.042 | 0.063 | 0.042 | 0.056 |
In Ph−B-ALL | 0.035 | 0.178 | 0.037 | 0.212 |
JAK2 mut; positive vs negative in full cohort | 3.02 | 0.045 | 3.309 | 0.021 |
In Ph−B-ALL | 3.728 | 0.049 | 3.780 | 0.044 |
JAK1 mut; positive vs negative in Ph−B-ALL | 6.808 | 0.004 | 6.562 | 0.005 |
NOTCH1 and/or FBXW7 mut; positive vs negative | ||||
In T-ALL | 0.204 | 0.055 | 0.223 | 0.069 |