Fig. 2From: Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stagesDNA damage repair (DDR) and chromatin remodeling gene mutations are associated with increased mutation number and may sensitize tumor to PARP inhibitor. a Patients with higher DDR and chromatin remodeling gene mutations numbers (n = 42) compared with patients with lower mutation numbers (n = 135). The black dotted line marks the median of the distribution. *** (p < 0.001), Mann-Whitney-Wilcoxon rank sum. b Composite image of axial contrast-enhanced computed tomography (CT) slicing through the liver demonstrates a progressive decrease in size of two hepatic metastases prior to treatment (left), 3 months (middle), and 5 months (right) after the initiation of olaparib therapyBack to article page