Fig. 6From: Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stagesMonitoring of lung cancer progression and response to therapy through longitudinal plasma ctDNA sequencing. a Compared with ctDNA mutations in five patients at two different time points, top shows the patients’ number and relative time point. Four patients demonstrated EGFR mutations. Mutation burden of patients 2 and 3 decreased after treatment. b Serial imaging at the time of plasma ctDNA testing indicated partial response for patient 3, minor response for patient 2, and progressive disease for patients 1, 4, and 5Back to article page