Fig. 4

Summary of individual predicted ixazomib systemic exposure for patients receiving ixazomib 4.0 mg. Ixazomib systemic exposures (AUC) were calculated for individual patients in the China Continuation study who underwent pharmacokinetic sampling, as well as for individual patients enrolled in other ixazomib studies (including the TOURMALINE-MM1 study), using the previously reported population pharmacokinetic model [26]. Red- and black-filled circles indicate the mean exposure in White patients and in other race categories, respectively. Numbers (brackets) at the top of the plot show the percent change in mean AUC (with 95% confidence intervals) in other race categories relative to White patients. Numbers at the bottom of the plot show the number of patients in each category