Fig. 2
From: Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
Combined depletion of ITGB4 and E-/P-selectin cooperatively reduces human pancreatic cancer xenograft tumor formation. shRNA-mediated knockdown of ITGB4 in PaCa5061 cells, survival of mice after s. c. xeno-transplantation of shControl vs. shITGB4 cells into E-/P-selectin wildtype vs. knockout Pfp−/−/Rag2−/− mice (endpoint: tumor size ~ 1.5 cm3) and resulting tumor weights at necropsy (A). Representative anti-ITGB4 immunostaining images taken from s. c. PaCa5061 xenograft tumors (B). All statistical comparisons indicated by asterisks were calculated vs. shControl/ WT. *p < 0.05; **p < 0.01