APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential

Table 1 Overexpression and correlation of APOBEC3s with mutation burden across cancers

Cancer type	APOBEC3(s) overexpressed*	Expression type*	Correlated tumor mutation burden(s)**	References
Multiple	3A, 3B*, 3F, and 3G	mRNA*	APOBEC3-induced	[27]
Adrenal	3B	mRNA* and protein	Overall	[44]
B-cell lymphoma	3B and 3C	mRNA	N/A	[45]
Bile duct	3A* and 3B (No healthy tissue control)	mRNA	APOBEC3-induced	[43]
Bladder	3B*	Protein	N/A	[35]
	3B	mRNA	Not detected	[27]
	3B	mRNA	N/A	[34]
	3A* and 3B*	mRNA*	APOBEC3-induced	[1, 46]
	3B1	mRNA and protein	N/A	[1]
Breast	3A, 3B, and 3H	mRNA*	APOBEC3-induced	[27]
	3B	mRNA	N/A	[34]
	3B*	mRNA*	APOBEC3-induced, overall	[22]
	3A* and 3B	mRNA*	APOBEC-induced	[47]
	3A, 3B, and C3-H	mRNA*	APOBEC3-induced, overall	[48]
Cervical	3B	mRNA	N/A	[34]
Esophageal	3B*	mRNA and protein*	APOBEC3-induced in PIK3CA	[39]
Gastric	3B*	Protein*	Overall	[37]
	3B	mRNA and protein	N/A	[38]
Glioma	3B, 3C, 3D, 3F, 3G, 3H	mRNA*	Overall	[51]
Head and neck	3B	mRNA	N/A	[34]
Kidney	3B	mRNA	N/A	[34]
Leukemia	3A	mRNA	N/A	[52]
Lung	3B*	mRNA*	APOBEC3-induced	[27]
	3B*	mRNA*	APOBEC3-induced, overall	[53]
	3B*	mRNA*	APOBEC3-induced	[54]
	3B	mRNA	N/A	[34]
	3B	mRNA	N/A	[36]
Nasopharyngeal	3B	Protein	N/A	[55]
Ovarian	3B	Protein	N/A	[42]
	3B	mRNA* and protein	Overall	[41]
	3B*	mRNA*	Overall	[56]
Pancreatic	3G	mRNA and protein	N/A	[49]
Penile	3A (In subset)	Protein	N/A	[57]
Prostate	3B	mRNA	N/A	[34]
Skin	3B	mRNA	N/A	[34]
Uterus	3B	mRNA	N/A	[34]

^*Indicates that a correlation was detected between the specified APOBEC3(s) and mutation burden(s). Some papers with both protein and mRNA expression only tested for correlations with one expression metric, so lack of an asterisk may indicate no relevant data rather than lack of statistical association
^**N/A indicates no relevant data, not lack of statistical association

ISSN: 1756-8722