Fig. 1

Genomic variants significantly associated with OS among the whole MDS cohort. A Volcano plot for genome-wide scanning of overall survival outcome association, respectively, for gene-based test of all nonsynonymous somatic coding variants (left), gene-based test of all somatic variants (middle), sliding window test of all somatic variants (right). B Heatmap of MDS genomic subgroups, respectively, using recurrent genomic alterations and K-means clustering. The survival curves associations of MDS genomic subgroups, respectively, using recurrent somatic mutations and cytogenetic abnormalities. C and D Heatmap and survival curve plots of MDS genomic subgroups using supervised clustering, respectively, for all genomic common variants and rare variants