Fig. 3

FR1 construct induces a broad upregulation of gene expression related to NK function. A Unsupervised clustering analysis showing expression levels of NK cell functional genes across all clusters. Red square bracket highlights up-regulated genes in FR1 NK cells in comparison with FR2 cells. B Top GO terms of biological processes enriched in FR1 NK cells versus FR2 NK cells by NK functional upregulation gene analysis (n = 3). Red frames highlight the biological processes related to chemotaxis. C and D GSEA analysis identifying up-regulated pathways related to NK cell function (C) and cytokine secretion (D) in FR1 NK cells in comparison with hnCD16 NK cells