Fig. 1
The CAR-HEMATOTOX score identifies patients at risk for severe hematotoxicity. A Relative distribution of neutrophil recovery phenotypes by CAR-HEMATOTOX score. Quick: sustained neutrophil recovery without a second dip below an ANC < 1000/µL. Intermittent: neutrophil recovery (ANC > 1500/µl) followed by a second dip with an ANC < 1000/µL after day 21. Aplastic: continuous severe neutropenia (ANC < 500/µL) ≥ 14 days. B Median duration of severe neutropenia (ANC < 500/µL) between days 0 and + 60 by CAR-HEMATOTOX score with whiskers indicating the 95% CIs. P-value determined by Mann–Whitney U test (****p < 0.0001). C Univariate analysis comparing the CAR-HEMATOTOX score with the duration of severe neutropenia (ANC < 500/µL) between CAR infusion and day + 60. The Spearman correlation coefficient and respective p-value is provided. The calculated slope (β1) of the linear regression curve is shown, indicating an average increase in the duration of severe neutropenia of 2.48 days for every increase of 1 in the score. Light shading indicates the 95% confidence bands of the best-fit lines from the simple linear regression. D Receiver operating characteristic (ROC) analysis studying the influence of the HT score on the binary outcome of severe neutropenia ≥ 14 days vs. 0–13 days. The area under the curve (AUC), p-value, and test characteristics (sensitivity, specificity) are provided