Fig. 3

The CAR-HEMATOTOX score identifies patients at risk for poor treatment outcomes. A Best overall tumor response at day 90 according to International Myeloma Working Group (IMWG) criteria. B–C Kaplan–Meier estimates of progression-free survival (PFS, B) and overall survival (OS, C) comparing HT high versus low patients. D–E Kaplan–Meier estimates of PFS (D) and OS (E) comparing low risk (HT score 0–1, green), intermediate to high-risk (score 2–4, yellow), and ultra high-risk patients (score ≥ 5, red). The superimposed table depicts the median and 95% confidence interval of survival estimates, as well as the p-values from the univariate Cox regression. The number at risk at each follow-up time point ist depicted below the x-axis. The p-value of the Mantel–Cox log-rank test is provided on the graph inset