Fig. 4

The CAR-HEMATOTOX score represents an independent adverse risk marker for PFS and OS on multivariable analysis. Forest plots of the multivariable Cox regression analysis for PFS (A) and OS (B) adjusted for the baseline risk factors of poor renal function (eGFR < 60 ml/min), LDH greater than upper limit of normal, ECOG performance status 2–4, plasma cell infiltration of the bone marrow greater than 50%, as well as HT risk group (high vs. low). Adjusted p-values accounting for the respective covariates are displayed on the graph inset. Variables reaching a p-value < 0.1 are highlighted in red (increased hazard ratio)