Fig. 2
From: GAS6-based CAR-T cells exhibit potent antitumor activity against pancreatic cancer
GAS6-CAR-T cells efficiently lyse TAM-positive human pancreatic cancer cell lines. The cytotoxicity of GAS6-CAR-T cells on TAM-low ASPC1 (A) and BxPC3 (B), TAM-high MIA PaCa2 (C), and PANC1 (D) cell lines was tested at varying effector-to-target (E/T) ratios for 24 h (n = 3). Quantification of IFN-γ and TNF-α release in response to coculture with Mock T cells or GAS6-CAR-T cells at an E/T ratio of 4:1 in ASPC1 (E), BxPC3 (F), MIA PaCa2 (G), and PANC1 (H), as measured by ELISA