Fig. 7
From: GAS6-based CAR-T cells exhibit potent antitumor activity against pancreatic cancer
Safety of GAS6-CAR-T cells in mice. A PCR analysis of TAM expression in a non-cancerous mouse cell line (NIH 3T3) and mouse tumor cell lines (4 T-1, Hepa1-6). B The cytotoxicity of GAS6-CAR-T cells on mouse cell lines at an E/T ratio of 4:1 for 24 h (n = 3). ELISA-based quantification of T-cell-induced IFN-γ (C) and TNF-α (D) release in the culture supernatants. Body weights in PANC1 xenograft mice (n = 3–6) (E) and PDX model (n = 3–4) (F) after receiving CAR-T cells. Pathological analysis of the indicated organs following hematoxylin and eosin staining at the experimental endpoint of PANC1 xenograft (G) and PDX model (H)