Fig. 4
From: Tumor-associated myeloid cells in cancer immunotherapy
Functional characteristics of heterogeneous TAMCs. (1) Bone marrow and spleen derived TAM includes anti-tumor M1 and pro-tumor M2. (2) TAN includes anti-tumor N1 and pro-tumor N2. (3) TADC populations mainly composed of three major subgroups, including pDC, cDC and moDC. (4) Bone marrow and spleen derived MDSC can not only reduce the anti-tumor activity of T cells, but also inhibit the function of NK cells, macrophages and dendritic cells, as well as induce Tregs. (5) EDMC shows strong immunosuppressive function by producing ROS, IL-10, TGF-β and inhibiting T cell production of IFN-γ. (6) B-MF significantly inhibits CD4+ T cells proliferation and IFN-γ production, phagocytizes apoptotic cells, and more effectively induces the production of Treg. (7) TRM induces Treg response, and also shows obvious pro-fibrotic transcriptional profile and has a causative role in tumor metastasis and spread. And there are spatial interactions of TRMs with tumor cells. An indication with an arrow indicates activation, induction, recruitment, apoptosisinhibition, cross-presentation, etc., while an indication without an arrow indicates inhibition, killing, etc.