Metabolites | Changes | Changes in macrophage polarization | Functions in environment |
---|---|---|---|
Glucose | Â | Increased in M1; Decreased in M2 | Â |
Pyruvate | Increased | M2 | Â |
Lactate | Increased | M2 | Tumour-promoting |
Cholesterol | Decreased | M2 | Tumour-promoting |
Triglyceride | Decreased | M2 | Tumour-promoting |
Diglyceride | Increased | M2 | Tumour-promoting |
Free fatty acid | Increased | M2 | Tumour-promoting |
α-ketoglutarate | Increased | M2 | Immunosuppressive |
Succinate | Increased | M1 | Â |
Citrate | Increased | M1 | Â |
Itaconate | Increased | M1 | Â |