Table 1 X-ray structures of NAE and NAE complex
Enzyme/ligand name | PDB code | Resolution (Ã…) | Total structure weight (kDa) | Atom count | Modeled residue count | Deposited residue count | Unique protein chains | References |
|---|---|---|---|---|---|---|---|---|
NAE(APPBP1/UBA3) | 1YOV | 2.60 | 220.58 | 14,604 | 1834 | 1962 | 2 | [62] |
APPBP1/UBA3/NEDD8/ATP | 1R4N | 3.60 | 469.48 | 31,744 | 4040 | 4144 | 3 | [73] |
APPBP1/UBA3/NEDD8 | 1R4M | 3.00 | 467.45 | 31,620 | 4040 | 4144 | 3 | [73] |
APPBP1/UBA3/UBC12 | 1TT5 | 2.60 | 223.43 | 14,637 | 1866 | 1982 | 3 | [74] |
APPBP1/UBA3/NEDD8/ATP/UBC12 | 2NVU | 2.80 | 188.89 | 13,090 | 1647 | 1683 | 4 | [75] |
APPBP1/UBA3/NEDD8 | 3DBR | 3.05 | 474.00 | 32,424 | 4098 | 4212 | 3 | [76] |
APPBP1/UBA3/NEDD8 | 3DBL | 2.90 | 474 | 32,577 | 4121 | 4212 | 3 | [76] |
APPBP1/UBA3/NEDD8 | 3DBH | 2.85 | 473.77 | 32,578 | 4123 | 4212 | 3 | [76] |
APPBP1/UBA3/NEDD8/MLN4924 | 3GZN | 3.00 | 244.27 | 16,050 | 2069 | 2158 | 3 | [77] |