Chemical structure | Number | IC50 (enzymatic level) | Target | IC50 (cellular level) | Cell line | Year | References |
---|---|---|---|---|---|---|---|
1 (MLN4924) | 4.00 nM | NAE | 52.48–5552.47 nM | MV-4-11, LNCaP, COLO 205, THP-1, HGC27, SW620, etc. | 2009 | [42] | |
2 | 2.80 μM | Pan-E1 | Unknown | HCT-116 | 2011 | [118] | |
3 | < 10.00 nM | NAE | 160.00 nM | K562 | 2011 | [119] | |
4 | < 10.00 μM | Pan-E1 | Unknown | A549, LNCap, MCF7, HeLa | 2013 | [120] | |
5 | 1.06 μM | NAE | 12.30 − 29.50 μM | Caco-2, MCF-7, Bcl-7402 | 2014 | [121] | |
6 | < 0.10 μM | NAE, UAE | 2.50 μM | A549 | 2015 | [122] | |
7 (TAS4464) | 0.96 nM | NAE | 1.60–460.00 nM | Patient-derived AML cells | 2019 | [114] | |
8 | 0.55 nM | NAE | 33.90–482.00 nM | HCT-116, HuTu80, Capan-1, MV-4–11, THP-1, etc. | 2021 | [123] | |
9 | 0.36 nM | NAE | 5.59–2164.76 nM | SW48, COLO 205, Capan-1, THP-1, MV-4-11, HCT-116, etc. | 2022 | [124] |