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Table 2 Subsequent therapies for patients who had progressive diseases after LCAR-B38M

From: Long-term remission and survival in patients with relapsed or refractory multiple myeloma after treatment with LCAR-B38M CAR T cells: 5-year follow-up of the LEGEND-2 trial

Drugs

Number of patients

Number of patients with evaluable response

Overall

response rate

CR rate

Total

44

36

61.1% (22/36)

38.9% (14/36)

Proteasome inhibitors

23

20

80.0% (16/20)

55.0% (11/20)

 Bortezomib

18

   

 Carfilzomib

1

 Ixazomib

5

Immunomodulatory drugs

21

19

63.2% (12/19)

36.8% (7/19)

 Thalidomide

5

   

 Lenalidomide

12

  

 Pomalidomide

7

  

Anti-CD38 mAb

9

7

71.4% (5/7)

42.9% (3/7)

Anti-BCMA CAR T cells

18

16

31.3% (5/16)

12.5% (2/16)

  1. Note The therapeutic effect induced by two or more drugs in a combinatory regimen was separately analyzed in different drug categories. BCMA, B-cell maturation antigen; CAR, Chimeric antigen receptor; CR, Complete response; mAb, Monoclonal antibody