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Table 2 In vitro sensitivities (EC50, pM) to target antigen-specific bispecific antibodies in PDAC cell lines

From: Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma

Cell line

EGFR

HER2

MSLN

c-MET

B7-H3

SW1990

0.1

23.6

5.8

26.7

155.4

BxPC-3

0.2

3.3

ND

14.9

 

Capan-2

0.1

1.4

ND

15.6

70.0

PANC-1

0.2

5.9

ND

16.3

 

Panc 10.05

0.1

2.2

4.3

20.2

227.1

  1. EGFR, epidermal growth factor receptor; HER2, human epidermal growth factor receptor 2; MSLN, mesothelin; c-MET, tyrosine-protein kinase Met; B7-H3, B7 homolog protein 3, CD276
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Journal of Hematology & Oncology

ISSN: 1756-8722

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