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Table 3 Avidities of EGFR and HER2 T-BsAbs

From: Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma

Specificity

Chip-bound protein

Binding valency

KD (M)

EGFR x EGFR

EGFR

2

1.33E-11

EGFR x HER2

EGFR

1

1.76E-09

EGFR x CD33

EGFR

1

1.96E-09

HER2 x HER2

HER2

2

1.12E-13

EGFR x HER2

HER2

1

2.75E-10

HER2 x CD33

HER2

1

6.65E-10

EGFR x EGFR

EGFR + HER2

2

1.42E-11

HER2 x HER2

EGFR + HER2

2

6.18E-13

EGFR x HER2

EGFR + HER2

2

6.04E-12

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Journal of Hematology & Oncology

ISSN: 1756-8722

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