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Table 5 ADTC sensitivities (EC50, pM) of SW1990 lines to EGFR and HER2 T-BsAbs

From: Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma

Cell line

CD33xCD33

EGFRxEGFR

EGFRxCD33

HER2xHER2

HER2xCD33

EGFRxHER2

SW1990

—

0.9

6.9

7.8

367.3

0.8

SW1990 EGFR-KO

—

—

—

38.3

557.5

229.5

SW1990 HER2-KO

—

0.2

6.4

—

—

8.2

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Journal of Hematology & Oncology

ISSN: 1756-8722

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