Fig. 2

Mechanisms of cellular pyroptosis. Various factors stimulate inflammasomes, which then induce pyroptosis by cleavage of GSDMD and GSDME by the caspase family, releasing IL-18 and IL-1β. LPS Lipopolysaccharide, NLRP1 NLR family pyrin domain containing (1), NLRP3 NLR family pyrin domain containing 3, NLRP4 NLR family pyrin domain containing 4, AIM2 Absent in melanoma (2), PYRIN MEFV innate immunity regulator, pyrin, GSDMD Gasdermin D, GSDME Gasdermin E, IL-18 Interleukin 18, IL-1β Interleukin 1β