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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis

Fig. 3

Mechanisms of cellular ferroptosis. Lipid peroxidation is affected when the ferroptosis-activation and ferroptosis-inhibition systems receive a corresponding stimulus. Lipid peroxidation and Fe2+ accumulation eventually induce ferroptosis. PUFA-PL: Polyunsaturated fatty acid-containing phospholipid. ACSL4: Acyl-CoA synthetase long chain family member 4. LPCAT3: Lysophosphatidylcholine acyltransferase 3. ALOX: Arachidonate lipoxygenase. POR: Cytochrome p450 oxidoreductase. TFR1 Transferrin receptor, DMT1 Ferrous ion membrane transport protein DMT1, GPX4 Glutathione peroxidase 4, GSH Glutathione, FSP1 Ferroptosis suppressor protein-1, CoQH2 ubiquinol, DHODH Dihydroorotate dehydrogenase, FTH1 Ferritin heavy chain 1 FTL1: Ferritin light polypeptide 1, FPN1 Solute carrier family 40 member 1, SLC7A11 Solute carrier family 7 member 11

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Journal of Hematology & Oncology

ISSN: 1756-8722

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