Fig. 5

Mechanisms of cellular disulfidptosis. Glucose starvation and high levels of SLC7A11 resulted in cellular NADPH depletion and cystine accumulation, which further led to F-actin collapse and ultimately induced cellular disulfidptosis. GLUT Glucose transporter, PPP Pentose phosphate pathway, SLC7A11 Solute carrier family 7 member 11, NADPH nicotinamide adenine dinucleotide phosphate. Interconnections between cell death