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Table 2 Ezatiostat Hydrochloride Liposomes for Injection Treatment Administration

From: Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra®, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

Phase 1
Doase Cohort (mg/m2) # of Patients Total # Cycles Administered Median # of Cycles per Patient (Range)
50 6 16 3 (1–5)
100 3 10 4 (2–4)
200 3 19 7 (4–8)
400 7 36 8 (1–8)
600 7 32 5 (1–8)
TOTAL 26 113 4 (1 – 8)
Phase 2
Treatment (600 mg/m 2 ) # of Patients Total # Cycles Administered Median # of Cycles per Patient (Range)
Dose Schedule 1 10 93 8 (4 – 17)
Dose Schedule 2 18 117 4 (1 – 19)
TOTAL 28 210 7 (1 – 19)