Rapid communication
Novel immunotherapeutic agents targeting tumor-site microenvironment are revolutionizing cancer therapy. Chimeric antigen receptor (CAR)-engineered T cells are widely studied for cancer immunotherapy. CD19-spe...
Journal of Hematology & Oncology 2017 10:166
Published on: 23 October 2017
Review
T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify...
Journal of Hematology & Oncology 2017 10:165
Published on: 23 October 2017
Review
Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and secondary resistance to currently available therapies in most cases. Therefore, despite recent advances in the treatment of this...
Journal of Hematology & Oncology 2017 10:164
Published on: 17 October 2017
Research
EPH (erythropoietin-producing hepatocellular) receptors are clinically relevant targets in several malignancies. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryona...
Journal of Hematology & Oncology 2017 10:161
Published on: 6 October 2017
Research
Xenotransplantation of patient-derived AML (acute myeloid leukemia) cells in NOD-scid Il2rγ null (NSG) mice is the method of choice for evaluatin...
Journal of Hematology & Oncology 2017 10:162
Published on: 6 October 2017
Erratum
Journal of Hematology & Oncology 2017 10:163
Published on: 6 October 2017
The original article was published in Journal of Hematology & Oncology 2016 9:112
Erratum
Journal of Hematology & Oncology 2017 10:160
Published on: 5 October 2017
The original article was published in Journal of Hematology & Oncology 2017 10:152
Research
Multiple primary cancers (MPC) have been identified as two or more cancers without any subordinate relationship that occur either simultaneously or metachronously in the same or different organs of an individu...
Journal of Hematology & Oncology 2017 10:158
Published on: 3 October 2017
Research
The stem cell factor spalt-like transcription factor 4 (SALL4) plays important roles in normal hematopoiesis and also in leukemogenesis. We previously reported that SALL4 exerts its effect by recruiting import...
Journal of Hematology & Oncology 2017 10:159
Published on: 3 October 2017
Review
Multiple myeloma (MM) is a malignant tumor of transformed plasma cells. MM pathogenesis is a multistep process. This cancer can occur de novo (rarely) or it can develop from monoclonal gammopathy of undetermin...
Journal of Hematology & Oncology 2017 10:157
Published on: 2 October 2017
Research
Myelofibrosis (MF) is associated with a variety of burdensome symptoms and reduced survival compared with age-/sex-matched controls. This analysis evaluated the long-term survival benefit with ruxolitinib, a J...
Journal of Hematology & Oncology 2017 10:156
Published on: 29 September 2017
Review
Cancer immunotherapy is the most exciting advancement in cancer therapy. Similar to immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T), bispecific antibody (BsAb) is attracting more and mo...
Journal of Hematology & Oncology 2017 10:155
Published on: 20 September 2017
Erratum
Journal of Hematology & Oncology 2017 10:154
Published on: 18 September 2017
The original article was published in Journal of Hematology & Oncology 2016 9:22
Short report
Reliable biomarkers of apatinib response in gastric cancer (GC) are lacking. We investigated the association between early presence of common adverse events (AEs) and clinical outcomes in metastatic GC patients.
Journal of Hematology & Oncology 2017 10:153
Published on: 5 September 2017
Review
Currently, conventional therapies for acute myeloid leukemia (AML) have high failure and relapse rates. Thus, developing new strategies is crucial for improving the treatment of AML. With the clinical success ...
Journal of Hematology & Oncology 2017 10:151
Published on: 29 August 2017
Research
A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective studies. The objective of the reported study was a pros...
Journal of Hematology & Oncology 2017 10:152
Published on: 29 August 2017
The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:160
Review
The past decade witnessed the rapid development of adult B-lineage acute lymphoblastic leukemia (ALL) treatment. Beyond the development of chemotherapy regimens, immunotherapy is starting a new era with unprec...
Journal of Hematology & Oncology 2017 10:150
Published on: 18 August 2017
Review
Gastric cancer is the third most common cause of cancer death worldwide, although it is not in the top 10 causes of cancer death in Northern America. Due to clear differences in incidence, screening, risk fact...
Journal of Hematology & Oncology 2017 10:149
Published on: 15 August 2017
Research
Structural chromosomal rearrangements that lead to expressed fusion genes are a hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed transcriptome sequencing of 134 primary ALL patient s...
Journal of Hematology & Oncology 2017 10:148
Published on: 14 August 2017
Review
With the development of evidence-based medicine, clinical trials have become necessary for investigating and validating the efficacy of new treatments. Over the past 10 years, several clinical trials of new an...
Journal of Hematology & Oncology 2017 10:147
Published on: 7 August 2017
Review
Gastrointestinal (GI) malignancies are the most prevalent tumors worldwide, with increasing incidence and mortality. Although surgical resection, chemotherapy, radiotherapy, and molecular targeted therapy have...
Journal of Hematology & Oncology 2017 10:146
Published on: 3 August 2017
Review
Spleen tyrosine kinase (Syk) is a cytosolic non-receptor protein tyrosine kinase (PTK) and is mainly expressed in hematopoietic cells. Syk was recognized as a critical element in the B-cell receptor signaling ...
Journal of Hematology & Oncology 2017 10:145
Published on: 28 July 2017
Review
Cancer is caused by uncontrollable growth of neoplastic cells, leading to invasion of adjacent and distant tissues resulting in death. Cancer cells have specific nutrient(s) auxotrophy and have a much higher n...
Journal of Hematology & Oncology 2017 10:144
Published on: 27 July 2017
Erratum
Journal of Hematology & Oncology 2017 10:143
Published on: 27 July 2017
The original article was published in Journal of Hematology & Oncology 2015 8:57
The original article was published in Journal of Hematology & Oncology 2015 8:50
Review
The advent of new immunotherapeutic agents in clinical practice has revolutionized cancer treatment in the past decade, both in oncology and hematology. The transfer of the immunotherapeutic concepts to the tr...
Journal of Hematology & Oncology 2017 10:142
Published on: 25 July 2017
