Figure 6From: ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedsideThe FLT3-ITD signaling pathways. The presence of FLT3-ITD induces ligand-independent receptor dimerization and activates three major signaling pathways including PI3K/AKT, MAPK and STAT5 pathways. These signalings are transferred to nucleus, which lead to the transcription of genes involved in cell proliferation and survival.Back to article page