Sequential real-time whole-body fluorescence imaging of HL60-RFP tumor growth in living mice. (A) Mice were treated with vehicle control. (B) Mice treated with ABT-869 (15 mg/kg/day). Arrow-pointed pictures show the direct view of distribution of blood vessel network on the tumor surface in the two representative mice. There is less of a tumor vessel network in ABT-869 treated mice. BF: bright field channel. RFP: RFP channel (The picture is modified from Leukemia Research 2008; 32:1091–1100 with permission) .