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Table 1 Summary of reported biological activities of garcinol

From: Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs

Activity Observations Reference
Anti-oxidant Efficient scavenging of free radicals Yamaguchi et al. [17]
   Yamaguchi et al.[28]
  Inhibition of NO and H2O2 production Sang et al. [18]
  Inhibition of NO and iNOS Generation Sang et al. [19]
  Inhibition of iNOS and COX-2 expression Liao et al. [31]
  Inhibition of NO accumulation Liao et al. [30]
Anti-bacterial Activity against methicillin-resistant Staphylococcus aureus Iinuma et al. [23]
   Rukachaisirikul et al. [22]
  Efficient killing of Helicobacter pylori Chatterjee et al. [20]
   Chatterjee et al. [21]
Anti-cancer Chemoprevention of colon tumorigenesis Tanaka et al. [34]
  Induction of caspase-3-mediated apoptosis Pan et al. [5]
  Loss of mitochondrial potential and activation of caspase-3 Matsumoto et al. [36]
  Induction of apoptosis Balasubramanyam et al. [40]
  Inhibition of tongue carcinogenesis Yoshida et al. [38]
  Modulation of arachidonic acid metabolism and inhibition of STAT-1 Hong et al. [29]
  Selective killing of colon cancer cells Hong et al. [33]
  Induction of apoptosis and inhibition of cell invasion Liao et al. [35]